{"id":"W2012513430","doi":"10.1039/b921912a","title":"A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors","year":2010,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Histone methyltransferase; Histone; EZH2; Methyltransferase; Epigenetics; Biochemistry; Biotinylation; Acetylation; Biology; Methylation; Chemistry; Molecular biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008358522,0.000180171,0.0002303931,0.0001037529,0.00005425561,0.00001952999,0.0001906017,0.0002467398,0.000005578518],"category_scores_gemma":[0.0002483008,0.0001824634,0.0002183915,0.0001780705,0.0000636127,0.000002988869,0.00002007745,0.0000795478,0.000001609395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121135,"about_ca_system_score_gemma":0.00008898139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004910236,"about_ca_topic_score_gemma":0.00003017906,"domain_scores_codex":[0.9985768,0.00008244377,0.0005342662,0.000413776,0.0001993477,0.0001933728],"domain_scores_gemma":[0.9987755,0.00002788403,0.0002306212,0.0005458714,0.0003363724,0.00008369045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005041712,0.0000804167,0.0002231789,0.0001358931,0.00003538416,6.820607e-7,0.00001897284,0.000121695,0.9974313,0.0001381191,0.00005790534,0.001706015],"study_design_scores_gemma":[0.000658269,0.0001485343,0.00009958691,0.00001530174,0.00005497908,0.000001633989,0.00001278144,0.002063454,0.9906628,0.00006454007,0.006018874,0.0001992775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.608896,0.0005610345,0.3895231,0.0001194486,0.0003449777,0.000435799,0.00005097248,0.00001077077,0.00005795362],"genre_scores_gemma":[0.9805362,0.00001144487,0.01862954,0.00004056272,0.0001729028,0.0001094158,0.0003647706,0.00003882221,0.00009637715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3716402,"threshold_uncertainty_score":0.7440643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007062271365308719,"score_gpt":0.3100012666108048,"score_spread":0.3029389952454961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}