{"id":"W2012538966","doi":"10.1371/journal.pmed.0050219","title":"Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism","year":2008,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":722,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw","keywords":"Aspergillus fumigatus; Posaconazole; Itraconazole; Voriconazole; Microbiology; Aspergillosis; Biology; Azole; Drug resistance; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004780177,0.0002590997,0.0003570593,0.0009722057,0.0003107091,0.0005950102,0.0003228397,0.0004670804,0.0008841833],"category_scores_gemma":[0.001249736,0.0001852104,0.0002390132,0.0006698712,0.0004284226,0.0003728292,0.0002865034,0.0004722967,0.0002230762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004638585,"about_ca_system_score_gemma":0.0001629819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001934291,"about_ca_topic_score_gemma":0.001579062,"domain_scores_codex":[0.9996271,0.00005127621,0.00004576468,0.0001178017,0.00007841239,0.00007964585],"domain_scores_gemma":[0.9983974,0.000229555,0.0009112822,0.0001172995,0.0002055357,0.0001388982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001509539,0.0000479522,0.9677584,0.00004507129,0.00004819078,0.001434098,0.0001326126,0.0001223401,0.02201002,0.00003964137,0.00008670544,0.008124033],"study_design_scores_gemma":[0.00001736941,0.0001668011,0.9858948,0.00002252408,0.00004666853,0.009188054,0.0001680704,0.0003173439,0.003789173,0.00004066555,0.0003407087,0.00000776974],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989095,0.0006624825,0.0001736083,0.00003632867,0.00000169864,0.000005586935,0.00004800587,0.000005860784,0.0001569324],"genre_scores_gemma":[0.9994739,0.0001962749,0.000181429,0.00001815458,0.00000883485,0.000002630017,0.00008662114,0.000001331153,0.00003085048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001934291,"threshold_uncertainty_score":0.003846049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041652586537615,"score_gpt":0.2658525990771546,"score_spread":0.2254360732117784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}