{"id":"W2012538966","doi":"10.1371/journal.pmed.0050219","title":"Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism","year":2008,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":722,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw","keywords":"Aspergillus fumigatus; Posaconazole; Itraconazole; Voriconazole; Microbiology; Aspergillosis; Biology; Azole; Drug resistance; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000345386,0.000192621,0.0008287553,0.0001695763,0.00004789869,8.285261e-7,0.0001194148,0.0001104122,0.0002671495],"category_scores_gemma":[0.0009762604,0.0001566433,0.00005943393,0.0005102182,0.0006940172,0.00007642832,0.00003956483,0.0001996255,0.000002626501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003810502,"about_ca_system_score_gemma":0.0001056398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009594011,"about_ca_topic_score_gemma":0.001197255,"domain_scores_codex":[0.9978774,0.00005950738,0.0007546964,0.0003921471,0.0006248853,0.0002913342],"domain_scores_gemma":[0.9986807,0.0001623598,0.0002339733,0.0005153294,0.0002490457,0.0001585566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002733119,0.0009432519,0.1304819,0.002498627,0.00009767852,0.0004229864,0.004817148,5.600021e-7,0.8479172,0.006875446,0.002976294,0.0002358279],"study_design_scores_gemma":[0.008453072,0.001918628,0.6353713,0.009497812,0.0003439607,0.00005610853,0.003941489,0.0001000941,0.330158,0.008321593,0.001266191,0.0005717389],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704918,0.009367345,0.0001292342,0.001027543,0.00007636841,0.0003727563,0.00001339658,0.0000251561,0.0184964],"genre_scores_gemma":[0.9935947,0.001983428,0.00157534,0.000126993,0.00006609588,0.000009746795,0.000007284485,0.0000199106,0.00261647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177592,"threshold_uncertainty_score":0.638773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04041652586537615,"score_gpt":0.2658525990771546,"score_spread":0.2254360732117784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}