{"id":"W2012540688","doi":"10.1016/j.taap.2008.06.004","title":"Progeric effects of catalase inactivation in human cells","year":2008,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Peroxisome; Catalase; Organelle; Reactive oxygen species; Hydrogen peroxide; Biochemistry; Peroxidase; Cell biology; Mitochondrion; Chemistry; Antioxidant; Biology; Enzyme; Oxidative phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311657,0.0003340307,0.00035367,0.000235603,0.0002043249,0.0003530069,0.0002143684,0.0003340024,0.003644445],"category_scores_gemma":[0.000386061,0.0001489705,0.0003725725,0.000357513,0.0004196117,0.0002033397,0.0002018144,0.0006181381,0.000545366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001941108,"about_ca_system_score_gemma":0.000402468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002379015,"about_ca_topic_score_gemma":0.00162419,"domain_scores_codex":[0.9997196,0.000110579,0.00002512584,0.00003571793,0.00003708629,0.00007196589],"domain_scores_gemma":[0.9997289,0.0001308349,0.00002329417,0.00006585244,0.00002311554,0.00002803342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004571324,0.0002237976,0.001139733,0.0001394336,0.00004221747,0.001385894,0.0002534904,0.0002240376,0.985283,0.0004366691,0.0004464695,0.005853909],"study_design_scores_gemma":[0.0001083879,0.002162542,0.005414958,0.00001089232,0.00005768704,0.001290754,0.0001518046,0.0004064686,0.9856418,0.0001285421,0.004617125,0.000009168428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910918,0.003578883,0.001175852,0.0002729686,0.0001164206,0.00003330046,0.0006667248,0.0001076203,0.002956388],"genre_scores_gemma":[0.9936847,0.001421469,0.0003773888,0.00008653344,0.00002315111,0.00002254524,0.001214458,0.00001563663,0.003154093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003644445,"threshold_uncertainty_score":0.01219183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007205996380114656,"score_gpt":0.2536796782308127,"score_spread":0.2464736818506981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}