{"id":"W2012540688","doi":"10.1016/j.taap.2008.06.004","title":"Progeric effects of catalase inactivation in human cells","year":2008,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Peroxisome; Catalase; Organelle; Reactive oxygen species; Hydrogen peroxide; Biochemistry; Peroxidase; Cell biology; Mitochondrion; Chemistry; Antioxidant; Biology; Enzyme; Oxidative phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009099235,0.0001544054,0.0002455014,0.0001103425,0.00008176539,0.000001499999,0.0001062341,0.0003025904,0.00003768839],"category_scores_gemma":[0.0000108367,0.0001588082,0.00002652834,0.0001377873,0.0003186506,0.000004286655,0.00009255269,0.0001872365,0.000003938982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002178885,"about_ca_system_score_gemma":0.00006792686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005106389,"about_ca_topic_score_gemma":0.000002757279,"domain_scores_codex":[0.9990596,0.00009757745,0.0002200491,0.0003207605,0.00004820159,0.000253866],"domain_scores_gemma":[0.9996544,0.00004080768,0.0001102818,0.0001044582,0.00002223783,0.00006788885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002278231,0.0003277172,0.002674809,0.00005958022,0.00004683399,0.00001118836,0.0001187799,0.00005017312,0.9952652,0.00008844867,0.0007717282,0.0003576582],"study_design_scores_gemma":[0.001858429,0.0003904502,0.002395727,0.000003000685,0.0000155577,0.00002553748,0.00001677575,0.000008633941,0.9939345,0.00003676315,0.001172098,0.0001424946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986166,0.0001888315,0.00003859279,0.00004028237,0.0001817164,0.0004837234,0.000003151199,0.00001311975,0.0004339726],"genre_scores_gemma":[0.9989503,0.0001624257,0.0001141436,0.0003561635,0.00009738345,0.0001961076,0.00003598128,0.00001653544,0.00007096224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001630606,"threshold_uncertainty_score":0.6476011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007205996380114656,"score_gpt":0.2536796782308127,"score_spread":0.2464736818506981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}