{"id":"W2012576981","doi":"10.1016/j.semcancer.2015.02.007","title":"Cancer prevention and therapy through the modulation of the tumor microenvironment","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":389,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Dalhousie University","funders":"Thales Group; Ministerstvo Zdravotnictví Ceské Republiky; Ministry of Education, Culture, Sports, Science and Technology; Grantová Agentura České Republiky; Center for Hierarchical Manufacturing, National Science Foundation; University of Glasgow; Univerzita Karlova v Praze; Marie Curie; National Cancer Institute; National Institutes of Health; Cancer Research UK","keywords":"Tumor microenvironment; Angiogenesis; Cancer research; Carcinogenesis; Tumor hypoxia; Biology; Cancer; Immunology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004971022,0.0008858998,0.001390145,0.002563603,0.0003473377,0.0009140957,0.0007808845,0.001125618,0.003056872],"category_scores_gemma":[0.0004202019,0.0002368845,0.0003907454,0.001910942,0.0006362916,0.001226452,0.0008131194,0.001908251,0.003043367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007897106,"about_ca_system_score_gemma":0.0007287678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008171187,"about_ca_topic_score_gemma":0.001696955,"domain_scores_codex":[0.9998296,0.00003002087,0.00001960466,0.00002899929,0.00007244236,0.00001923414],"domain_scores_gemma":[0.9998456,0.00005305016,0.00001958413,0.000009622093,0.000048199,0.00002397584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006424444,0.0001005142,0.0001433919,0.009373181,0.00007402802,0.0001937712,0.00005822652,0.0004072644,0.004103293,0.007277725,0.03356289,0.9446414],"study_design_scores_gemma":[0.000009508919,0.00004771302,0.0003791299,0.0009118412,0.00002841387,0.000622711,0.00002582008,0.00005445896,0.0005360597,0.001412893,0.9959624,0.000009222663],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001319128,0.9974631,0.0002104285,0.0002909155,0.0002276975,0.000006886025,0.00001886454,0.00001351795,0.001636665],"genre_scores_gemma":[0.0008717753,0.9974602,0.0002872812,0.0001643891,0.0001398668,0.000009838672,0.00002822985,0.000002301763,0.001036119],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003056872,"threshold_uncertainty_score":0.01022631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697428158445467,"score_gpt":0.401980810122917,"score_spread":0.3450065285384624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}