{"id":"W2012597729","doi":"10.1016/s0960-894x(03)00619-x","title":"Synthesis and Structure–activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health; Ryerson University","keywords":"Chemistry; Aryl; Stereochemistry; Chemical synthesis; Stereoselectivity; Molecule; Structure–activity relationship; High-performance liquid chromatography; In vitro; Biochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005707344,0.0003367263,0.0005104156,0.00003872662,0.0002005914,0.0000146664,0.0004048992,0.0003285678,0.0003754867],"category_scores_gemma":[0.002026112,0.0002589373,0.0002516478,0.0003188038,0.0006706804,0.000009492464,0.00012764,0.000370282,0.000001796167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004805925,"about_ca_system_score_gemma":0.0001008997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000847439,"about_ca_topic_score_gemma":0.000005876861,"domain_scores_codex":[0.9979191,0.0002147899,0.0005254342,0.0005714047,0.0004481192,0.000321149],"domain_scores_gemma":[0.9982977,0.0002261186,0.0004740428,0.0007318154,0.0001006805,0.0001696781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000331714,0.00007192422,0.01119666,0.00015515,0.0001955281,0.000001465197,0.00005612552,0.000001574199,0.9872385,0.00001605573,0.0004343669,0.0005994456],"study_design_scores_gemma":[0.0003298968,0.00002760278,0.006096243,0.00008349192,0.0002382214,0.00002919484,0.0001626459,0.000002081712,0.9910902,0.00006572308,0.001608888,0.0002657523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975355,0.0007959921,0.00007012048,0.00102807,0.00006439528,0.0001336117,0.00007946701,0.00001014221,0.0002827274],"genre_scores_gemma":[0.9991174,0.00009388654,0.0002803533,0.0001931615,0.0001535429,0.000008415598,0.00002704025,0.00003415368,0.00009198563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005100421,"threshold_uncertainty_score":0.9999863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012883357274453,"score_gpt":0.2299048714596792,"score_spread":0.2197760378869346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}