{"id":"W2012678328","doi":"10.1006/bbrc.2000.3553","title":"The Slow-Binding Inhibition of Cathepsin K by Its Propeptide","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"","keywords":"Protein precursor; Chemistry; Cathepsin O; Cathepsin; Cathepsin B; Cathepsin L; Cathepsin A; Recombinant DNA; Peptide; Cysteine; Biochemistry; Cathepsin H; Enzyme; Cathepsin C; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324908,0.0003184768,0.0002497339,0.00012602,0.0001336459,0.0003375832,0.0003059314,0.0003207768,0.002002568],"category_scores_gemma":[0.0003917433,0.0001743027,0.0003147361,0.0001129068,0.0002118724,0.0002693086,0.0001953071,0.0007068999,0.0006232145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901402,"about_ca_system_score_gemma":0.0002716382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162992,"about_ca_topic_score_gemma":0.0008981802,"domain_scores_codex":[0.9998568,0.00002212269,0.00001311008,0.00002138807,0.00003497914,0.00005158398],"domain_scores_gemma":[0.9998255,0.00005558957,0.00003094737,0.00003066902,0.00001920527,0.00003806791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006412251,0.00003825986,0.0001786394,0.00007767068,0.00001486936,0.0001013005,0.00001727045,0.0001005891,0.9947373,0.0003504525,0.0001675164,0.003574912],"study_design_scores_gemma":[0.00005149149,0.0003665773,0.002265645,0.000005130158,0.000009003209,0.0005285526,0.00001198916,0.0005290292,0.994101,0.00006625746,0.002057876,0.000007305053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989904,0.003638515,0.003228606,0.0002143556,0.00008279432,0.00004139003,0.0003035476,0.00006386243,0.002522864],"genre_scores_gemma":[0.9932141,0.001023181,0.001199606,0.00008039663,0.00001913666,0.00002809269,0.0004151523,0.00001552299,0.004004794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002568,"threshold_uncertainty_score":0.006699264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04028185808229493,"score_gpt":0.3299445801244054,"score_spread":0.2896627220421105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}