{"id":"W2012715007","doi":"10.1016/j.radonc.2011.05.058","title":"Translational control is a major contributor to hypoxia induced gene expression","year":2011,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; KWF Kankerbestrijding; Ontario Institute for Cancer Research","keywords":"Gene expression; Gene; Transcription (linguistics); Biology; Messenger RNA; Translational regulation; DU145; Hypoxia (environmental); Regulation of gene expression; mTORC1; Transcriptional regulation; Signal transduction; Translational efficiency; Transcription factor; Cancer research; Molecular biology; Cell biology; Translation (biology); Genetics; Chemistry; Cancer cell; Cancer; LNCaP; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004530453,0.0003801263,0.0004200281,0.0003968229,0.0005709888,0.0007805158,0.0004093538,0.0004341661,0.003282577],"category_scores_gemma":[0.0004043134,0.0002445054,0.0004034958,0.0004104216,0.000571706,0.0004719131,0.0003998314,0.0006734549,0.000784635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005311043,"about_ca_system_score_gemma":0.0004383931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960265,"about_ca_topic_score_gemma":0.0007597948,"domain_scores_codex":[0.9997155,0.00004929956,0.00001538544,0.00007267537,0.00008111715,0.00006600346],"domain_scores_gemma":[0.9996135,0.00007858635,0.0001090059,0.00005616704,0.0000722596,0.00007056901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002348164,0.00004907315,0.00114264,0.00009700318,0.00001216017,0.0001392333,0.00004368446,0.0001241799,0.9867871,0.002656667,0.0003771727,0.008336324],"study_design_scores_gemma":[0.00003652332,0.0007918762,0.05565377,0.00003930071,0.00004312249,0.0009948545,0.0001775943,0.002059512,0.9190829,0.003324584,0.01776867,0.00002727957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8904798,0.03532124,0.04803139,0.003937899,0.0008299871,0.0001784842,0.001262223,0.0008304637,0.01912857],"genre_scores_gemma":[0.9775556,0.005709436,0.004265859,0.000320412,0.0003977547,0.00007088445,0.001411723,0.0001155305,0.01015281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003282577,"threshold_uncertainty_score":0.01098132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01704975581803149,"score_gpt":0.2737218164028621,"score_spread":0.2566720605848307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}