{"id":"W2012716329","doi":"10.1016/j.jmb.2010.03.053","title":"Structure-Based Design of a Photocontrolled DNA Binding Protein","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Leucine zipper; bZIP domain; DNA-binding domain; DNA; Chemistry; Fusion protein; Biophysics; Protein structure; Biochemistry; Zipper; Circular dichroism; Binding domain; Binding site; Crystallography; Biology; Transcription factor; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397799,0.000325078,0.000426653,0.0001905742,0.0004011633,0.0005354056,0.0007482468,0.0006974859,0.001050539],"category_scores_gemma":[0.0003006654,0.0003053387,0.0003837828,0.0001503513,0.0003439003,0.0002282828,0.0002311306,0.0009588439,0.000606871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165128,"about_ca_system_score_gemma":0.0007135944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267521,"about_ca_topic_score_gemma":0.00187253,"domain_scores_codex":[0.9998604,0.00001735953,0.000008972656,0.00003337251,0.00005481766,0.00002509458],"domain_scores_gemma":[0.9998833,0.00002165271,0.00002442538,0.00000937385,0.00002330237,0.00003803585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009057128,0.00008140916,0.00007557064,0.00005323147,0.000009893558,0.00007255175,0.0000210753,0.002396638,0.9926832,0.001101609,0.0001031493,0.00331112],"study_design_scores_gemma":[0.00004648575,0.000223493,0.0002672684,0.000005907667,0.00001481651,0.00008742236,0.00001301206,0.008893025,0.9860125,0.0001262225,0.004297209,0.00001270729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8899721,0.001559276,0.1014856,0.0008092973,0.0002284091,0.0004371751,0.0003582001,0.0006862524,0.004463643],"genre_scores_gemma":[0.9232597,0.0006338696,0.06963354,0.000247419,0.0000187021,0.0001836271,0.0003919688,0.0000748294,0.005556263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267521,"threshold_uncertainty_score":0.008453608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02676152727602648,"score_gpt":0.3249590201904846,"score_spread":0.2981974929144581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}