{"id":"W2012727770","doi":"10.1097/fpc.0b013e328342f5b1","title":"Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity","year":2011,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Nonsynonymous substitution; Organic anion-transporting polypeptide; Solute carrier family; Organic anion transporter 1; Biology; Chemistry; Molecular biology; Biochemistry; Gene; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675966,0.0004114023,0.0001991244,0.0002988503,0.0001520841,0.0002035591,0.0001407421,0.0003931222,0.001344844],"category_scores_gemma":[0.0004273362,0.0000963035,0.0002670255,0.0003078279,0.0002082632,0.00006340678,0.00009669652,0.0002896343,0.0002976356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001549213,"about_ca_system_score_gemma":0.0001049475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000931,"about_ca_topic_score_gemma":0.0007649894,"domain_scores_codex":[0.9997867,0.00005117813,0.00002373809,0.00007862088,0.00003784335,0.00002197153],"domain_scores_gemma":[0.9997985,0.00006368743,0.00007419178,0.00001397726,0.00002231622,0.00002747152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001229984,0.00008943561,0.09366294,0.00006670751,0.00009050279,0.001371577,0.0001390901,0.0002430578,0.8977112,0.0001035803,0.00009002418,0.005201879],"study_design_scores_gemma":[0.0001776804,0.001186577,0.6697937,0.00004683647,0.0002974298,0.01494732,0.0002191369,0.004899466,0.3046565,0.0002714444,0.003473462,0.00003035498],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983895,0.0001778026,0.0009806757,0.0000321671,0.000004766716,0.00001145967,0.0002357516,0.000009219974,0.0001586441],"genre_scores_gemma":[0.998004,0.00007240033,0.001345984,0.00002963663,0.000005247595,0.00001255981,0.0002959995,0.0000108127,0.0002233354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344844,"threshold_uncertainty_score":0.004498899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04942673290203325,"score_gpt":0.2808709943109022,"score_spread":0.231444261408869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}