{"id":"W2012799867","doi":"10.1073/pnas.1402393111","title":"In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Cancer Institute; School of Medicine, New York University; York University; National Science Foundation","keywords":"Transcription factor; Protein–protein interaction; Cell biology; Coactivator; CREB-binding protein; Drug discovery; CREB; In vivo; Small molecule; Biology; Hypoxia-Inducible Factor 1; Computational biology; Chemistry; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588549,0.0001879069,0.0001378744,0.00008295296,0.00007726331,0.0001211918,0.0001835112,0.0001491004,0.0008995172],"category_scores_gemma":[0.00007873743,0.00008519136,0.00009884186,0.00005682386,0.0001185519,0.00008636579,0.00008285991,0.0002776818,0.0001440769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436174,"about_ca_system_score_gemma":0.0001334107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002585531,"about_ca_topic_score_gemma":0.0004159707,"domain_scores_codex":[0.9999435,0.00001403978,0.000003034744,0.00001023648,0.00001277859,0.00001646358],"domain_scores_gemma":[0.9999621,0.00000956931,0.00001289481,0.00000357956,0.000002984301,0.000008935669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002250734,0.00008228108,0.00007640377,0.00002222957,0.000004185808,0.00002093298,0.000005805199,0.0004894318,0.9971834,0.000177801,0.00005598179,0.001656425],"study_design_scores_gemma":[0.00003964993,0.0007885869,0.0003180766,0.00000149605,0.000005357495,0.0000484629,0.000004183754,0.00159063,0.9961171,0.00003267346,0.001051671,0.000002090189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902999,0.0008130643,0.006711342,0.0001035381,0.00002209818,0.00006888634,0.0001512467,0.00008433212,0.001745639],"genre_scores_gemma":[0.9954699,0.0004514804,0.002810672,0.00003716848,0.000004622639,0.00003861529,0.0001210522,0.000008108976,0.001058352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008995172,"threshold_uncertainty_score":0.0030092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933791631904264,"score_gpt":0.2797945999682336,"score_spread":0.2604566836491909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}