{"id":"W2012801471","doi":"10.1128/mcb.22.1.257-269.2002","title":"v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Calpastatin; Calpain; Focal adhesion; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Biology; Phosphorylation; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023589,0.0001512088,0.0001533797,0.00005073961,0.0001145397,0.00001122486,0.0001012886,0.0002272912,0.00001970969],"category_scores_gemma":[0.00003541147,0.0001117822,0.0001195702,0.0001271293,0.0001111743,0.000004864179,0.00004370118,0.00008019116,0.000003880268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554194,"about_ca_system_score_gemma":0.00001423204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002063729,"about_ca_topic_score_gemma":0.000004424725,"domain_scores_codex":[0.9989193,0.0002356208,0.0002997531,0.0002672441,0.0001052908,0.0001728043],"domain_scores_gemma":[0.9994279,0.000007348404,0.000136355,0.0002988687,0.00007751535,0.00005197812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002795527,0.00002762708,0.000278961,0.0000686351,0.0000322066,6.359854e-7,0.00008353051,0.0001610885,0.9917996,0.002414266,0.00003217537,0.005073318],"study_design_scores_gemma":[0.0006465025,0.0002174978,0.001209265,0.00003001453,0.00003326648,0.00002603323,0.00009840885,0.01590257,0.9797435,0.000207012,0.001721087,0.0001648341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662589,0.0005149794,0.03155403,0.0002839098,0.0001468222,0.0006109037,0.000008031572,0.00001834157,0.000604127],"genre_scores_gemma":[0.9993566,0.00001152099,0.0001499082,0.00008202506,0.00005350764,0.00003815555,0.00007711176,0.00001605555,0.0002150971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03309776,"threshold_uncertainty_score":0.4558344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007440746702502794,"score_gpt":0.1903902395340208,"score_spread":0.182949492831518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}