{"id":"W2012812562","doi":"10.1016/j.bmcl.2009.12.086","title":"Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): Optimization of the 1-substituent","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Substituent; In vivo; PI3K/AKT/mTOR pathway; Morpholine; Selectivity; Potency; Stereochemistry; Pharmacology; Structure–activity relationship; In vitro; Combinatorial chemistry; Biochemistry; Medicinal chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000334675,0.0005305166,0.0004340958,0.0002861196,0.0002266128,0.0003369798,0.0004422528,0.0002846813,0.001815138],"category_scores_gemma":[0.0002146803,0.0002236687,0.0001639697,0.000292831,0.0002257418,0.0002724968,0.0002610892,0.0004551855,0.0004079735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004179317,"about_ca_system_score_gemma":0.0004140238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00112338,"about_ca_topic_score_gemma":0.004023003,"domain_scores_codex":[0.9998251,0.00004316151,0.00001584725,0.0000259064,0.00004261588,0.00004735913],"domain_scores_gemma":[0.9999447,0.00000844287,0.00001509391,0.000005145705,0.000008943578,0.00001760821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002487189,0.0004608851,0.000591201,0.0005821802,0.00005069637,0.0009552767,0.0001606194,0.005814965,0.911087,0.004376087,0.002160153,0.07127378],"study_design_scores_gemma":[0.001484853,0.006536372,0.002865687,0.00004701957,0.0001622801,0.001626626,0.00004815265,0.006354953,0.9433778,0.0004169387,0.03700201,0.00007726237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958156,0.01775565,0.009388854,0.0004638313,0.0002535084,0.000379404,0.001111841,0.0003449818,0.01214594],"genre_scores_gemma":[0.9838138,0.006577207,0.005487881,0.0001394653,0.0000385393,0.00006580341,0.0005451016,0.00002020996,0.003312024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815138,"threshold_uncertainty_score":0.006072223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003483004923445589,"score_gpt":0.1986558679978138,"score_spread":0.1951728630743683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}