{"id":"W2012819199","doi":"10.1158/0008-5472.can-09-4519","title":"Tumor Antigen Epitopes Interpreted by the Immune System as Self or Abnormal-Self Differentially Affect Cancer Vaccine Responses","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Epitope; MUC1; Immune system; Glycopeptide; Biology; Antigen; T cell; Molecular biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002427402,0.0004411485,0.0006528536,0.0003397481,0.001364854,0.000188226,0.001642275,0.0003844784,0.005915092],"category_scores_gemma":[0.00041966,0.0002656458,0.0002212481,0.0006500301,0.0004692891,0.0002232369,0.0004376324,0.002170338,0.0007124032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912507,"about_ca_system_score_gemma":0.001191399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006318148,"about_ca_topic_score_gemma":0.0006785219,"domain_scores_codex":[0.9943714,0.002798442,0.0006279272,0.0006458387,0.0002437525,0.001312637],"domain_scores_gemma":[0.996236,0.001863106,0.0002085426,0.001181386,0.0004443061,0.00006663109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01353757,0.0001959282,0.001297604,0.0001244088,0.001024028,0.00003439873,0.001887625,5.723704e-7,0.9653813,0.0002226252,0.009138762,0.007155153],"study_design_scores_gemma":[0.00216922,0.0006274284,0.0134835,0.0002804776,0.00005292726,0.0002551975,0.0006701159,0.000008276935,0.783108,0.000007470504,0.1990018,0.0003355191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308637,0.06311518,0.00001234515,0.001308587,0.002636853,0.001243477,0.0001697169,0.0003203936,0.0003297011],"genre_scores_gemma":[0.973163,0.005941234,0.00001370652,0.0001605086,0.0001936433,0.001044342,0.00003777807,0.00009173639,0.01935403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898631,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985421840707701,"score_gpt":0.3463455309885278,"score_spread":0.3264913125814508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}