{"id":"W2012847512","doi":"10.1128/aac.04829-14","title":"Simian-Tropic HIV as a Model To Study Drug Resistance against Integrase Inhibitors","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Raltegravir; Virology; Integrase; Elvitegravir; Simian immunodeficiency virus; Dolutegravir; Biology; Integrase inhibitor; Drug resistance; Viral replication; Lentivirus; Virus; Viral evolution; Viral load; Genetics; Viral disease; Human immunodeficiency virus (HIV); Gene; Antiretroviral therapy; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004606906,0.0005881621,0.0004130439,0.0006568903,0.000317878,0.0003762917,0.0006411673,0.0004243342,0.001760291],"category_scores_gemma":[0.000177569,0.0001990493,0.0004042494,0.0003505285,0.0002853487,0.0003598253,0.0003029722,0.001367272,0.0004076891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004778272,"about_ca_system_score_gemma":0.0003503684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542914,"about_ca_topic_score_gemma":0.001759485,"domain_scores_codex":[0.9996756,0.0001109121,0.00002343144,0.00005718251,0.00007799563,0.00005492641],"domain_scores_gemma":[0.9998411,0.00004256612,0.000028581,0.00002739969,0.0000189744,0.00004137817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002775879,0.0002639702,0.0006185318,0.00005235717,0.00001567414,0.0001387926,0.00006264504,0.0005318279,0.9954321,0.0007974562,0.0001701768,0.001638938],"study_design_scores_gemma":[0.0002998705,0.008336982,0.006350594,0.00004436152,0.00008069367,0.001815627,0.00019089,0.01205527,0.9567143,0.000968089,0.01310813,0.00003507706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854351,0.002692869,0.006267496,0.0002985167,0.00009958298,0.0002471894,0.001563022,0.0001233473,0.003272778],"genre_scores_gemma":[0.9734678,0.002723348,0.01810382,0.0001440184,0.00003568981,0.0003048858,0.001814812,0.00005577193,0.003349659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760291,"threshold_uncertainty_score":0.00588882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0220570026084317,"score_gpt":0.2842469318004697,"score_spread":0.262189929192038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}