{"id":"W2012855647","doi":"10.1371/journal.pone.0099988","title":"DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Cancer research; Sting; Stimulator of interferon genes; Tumor necrosis factor alpha; Macrophage; Necrosis; Medicine; Lung; Pathology; Lewis lung carcinoma; Inflammation; In vivo; Cancer; Pharmacology; Biology; Metastasis; Immunology; Receptor; Internal medicine; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001898582,0.0004116398,0.0001936876,0.0003847868,0.0001631743,0.0002092539,0.0002425811,0.0003954389,0.001880823],"category_scores_gemma":[0.00008171296,0.0002254847,0.0003075454,0.0001863341,0.0002850216,0.0001888999,0.0001860586,0.0007645994,0.000420934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003636514,"about_ca_system_score_gemma":0.0002377336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099582,"about_ca_topic_score_gemma":0.001718744,"domain_scores_codex":[0.9997589,0.00004922803,0.00002362117,0.00004815237,0.00005196924,0.00006817794],"domain_scores_gemma":[0.9998241,0.00003001701,0.000051234,0.00002857836,0.00001083027,0.00005520415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001430208,0.00006075772,0.00009633186,0.00001994063,0.000003087436,0.00004422672,0.00001379655,0.00004751917,0.9990466,0.0001154448,0.00002659472,0.0003825671],"study_design_scores_gemma":[0.00001784031,0.000690484,0.001554576,0.000002751412,0.000007593009,0.0001594513,0.00001695753,0.0005767255,0.9960272,0.0000303072,0.0009142603,0.000001820202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953152,0.0007397872,0.001759837,0.00008914623,0.00003043026,0.00006084876,0.0006589905,0.0001176944,0.001228127],"genre_scores_gemma":[0.991193,0.0006254493,0.001830004,0.00004833536,0.00001169642,0.0001063076,0.0008419926,0.00003133341,0.005311999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880823,"threshold_uncertainty_score":0.006291986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542612229614612,"score_gpt":0.2228130163562384,"score_spread":0.1973868940600923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}