{"id":"W2012855647","doi":"10.1371/journal.pone.0099988","title":"DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Cancer research; Sting; Stimulator of interferon genes; Tumor necrosis factor alpha; Macrophage; Necrosis; Medicine; Lung; Pathology; Lewis lung carcinoma; Inflammation; In vivo; Cancer; Pharmacology; Biology; Metastasis; Immunology; Receptor; Internal medicine; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004800232,0.0002815599,0.0004512247,0.0001492198,0.0003866225,0.0000804142,0.0002515951,0.0001890114,0.0001447571],"category_scores_gemma":[0.0001389443,0.0002271843,0.00008404813,0.0001796114,0.0002069703,0.0001011975,0.0001984291,0.0005893429,0.00007860277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001090268,"about_ca_system_score_gemma":0.00007287296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001061576,"about_ca_topic_score_gemma":0.0004590782,"domain_scores_codex":[0.9980354,0.0004073478,0.0004999649,0.0004723491,0.00008326029,0.0005017113],"domain_scores_gemma":[0.9988865,0.0003299074,0.0002305335,0.000438706,0.00007592935,0.00003838071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002424964,0.0005765547,0.02683197,0.0001218815,0.0001419193,0.00001693106,0.001225186,0.00001396141,0.9703529,0.00001580614,0.00003720116,0.0004231854],"study_design_scores_gemma":[0.001895429,0.0003217929,0.101145,0.0004037996,0.0001898403,0.0000585772,0.0002352318,0.0002832458,0.8940311,0.000006110024,0.001067999,0.0003618538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914831,0.006956796,0.0001055714,0.0001229777,0.0002342597,0.000578932,0.0000251298,0.00005486026,0.0004383533],"genre_scores_gemma":[0.9968449,0.001534777,0.0001242044,0.0001711701,0.00008609006,0.00009175919,0.00008024438,0.00004550414,0.001021338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07632177,"threshold_uncertainty_score":0.9264307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542612229614612,"score_gpt":0.2228130163562384,"score_spread":0.1973868940600923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}