{"id":"W2012874922","doi":"10.1089/hum.2015.015","title":"Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies","year":2015,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cardiff University; Higher Education Funding Council for Wales; Cancer Research Wales; Cancer Research UK; Health and Care Research Wales","keywords":"Oncolytic virus; Transduction (biophysics); Oncolytic adenovirus; Fibroblast growth factor receptor 1; Cancer research; Epidermal growth factor receptor; Ovarian cancer; Biology; Virotherapy; Viral vector; Epidermal growth factor; Genetic enhancement; Cell culture; Cancer; Receptor; Fibroblast growth factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001458601,0.0002026742,0.0001751611,0.00006238676,0.0002239266,0.00004953532,0.0001852585,0.0001110318,0.00009146906],"category_scores_gemma":[0.0000295569,0.0001366137,0.00004710751,0.0001063059,0.0003025793,0.00001439545,0.00007760464,0.0001032853,0.000002772996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003459312,"about_ca_system_score_gemma":0.0001860661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003004405,"about_ca_topic_score_gemma":0.0004759708,"domain_scores_codex":[0.9984748,0.0004672113,0.0002408429,0.0003254397,0.0002870659,0.0002046351],"domain_scores_gemma":[0.9991261,0.00002108855,0.0001586845,0.0003108741,0.0003067282,0.00007649956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009520177,0.00003441964,0.001189831,0.000006639317,0.0001323503,3.102117e-7,0.005920805,0.0001115459,0.9586101,0.00002811606,0.0003363448,0.0326775],"study_design_scores_gemma":[0.00214348,0.002674769,0.002533476,0.00001197025,0.00001215367,0.000004485174,0.001583966,0.0001660752,0.9784602,0.007787763,0.004385053,0.0002366425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533589,0.04550063,0.00003187931,0.0004105004,0.00003707672,0.00051272,0.000007949556,0.00001109266,0.0001292176],"genre_scores_gemma":[0.9965353,0.002231581,0.000268071,0.0002405703,0.0002750224,0.000119178,0.0001149011,0.00003689589,0.0001784913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04326905,"threshold_uncertainty_score":0.5570943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04197510785302481,"score_gpt":0.334886979359024,"score_spread":0.2929118715059992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}