{"id":"W2012899108","doi":"10.4161/cbt.11.9.15183","title":"Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267","year":2011,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre for Drug Research and Development; BC Cancer Agency","funders":"BC Cancer Agency","keywords":"Docetaxel; Cancer research; Medicine; Luciferase; Drug; Cell culture; Breast cancer; Tumor progression; Cancer; Paclitaxel; Pharmacology; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001615558,0.0005617828,0.0005877925,0.0004776339,0.0004289246,0.001076494,0.000342219,0.0006045642,0.001008585],"category_scores_gemma":[0.0005446118,0.0003100492,0.0004852323,0.0005458395,0.0004195947,0.0005330776,0.0002747102,0.0008766559,0.0005566102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007693784,"about_ca_system_score_gemma":0.0006486297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004287951,"about_ca_topic_score_gemma":0.007637672,"domain_scores_codex":[0.9991013,0.0002434849,0.0001136424,0.0001854855,0.0002685334,0.00008757621],"domain_scores_gemma":[0.9993817,0.000150588,0.0001219917,0.0001100442,0.0001880259,0.00004763844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229627,0.0001429533,0.001327248,0.00008628103,0.0000133041,0.00002330527,0.00004118018,0.0002462033,0.9956853,0.0001590704,0.0001231857,0.002028991],"study_design_scores_gemma":[0.00001689162,0.001048043,0.00489025,0.000008414931,0.00002522711,0.0002306575,0.00004024835,0.002461325,0.9885232,0.00004442181,0.002701303,0.00001007642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291677,0.00345897,0.05745462,0.0005007053,0.0002156053,0.0005461844,0.003126853,0.0005217023,0.005007562],"genre_scores_gemma":[0.9236667,0.002621123,0.06377849,0.000191379,0.00002742237,0.0005876322,0.003100892,0.0001266509,0.005899633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004287951,"threshold_uncertainty_score":0.008543968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0916860555645962,"score_gpt":0.3604379321946317,"score_spread":0.2687518766300355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}