{"id":"W2012908693","doi":"10.1038/modpathol.2009.49","title":"SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer","year":2009,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Institutes of Health; Gary Bennett Family Fund; National Cancer Institute; Entertainment Industry Foundation","keywords":"Cancer research; Biology; MLH1; Microsatellite instability; DNA methylation; Epigenetics; Colorectal cancer; Cancer; Carcinogenesis; Histone deacetylase; Genetics; Histone; DNA mismatch repair; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179847,0.0001944867,0.000345475,0.0013105,0.0002540905,0.0002679622,0.0002433813,0.000348174,0.001727727],"category_scores_gemma":[0.0006244929,0.0003147301,0.0002572445,0.0006959501,0.0002968945,0.0001536583,0.0002206122,0.0003768408,0.0002358561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261964,"about_ca_system_score_gemma":0.0001437447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212056,"about_ca_topic_score_gemma":0.001659742,"domain_scores_codex":[0.9998413,0.00003260803,0.00001977516,0.0000344326,0.0000403028,0.00003152038],"domain_scores_gemma":[0.9989797,0.0001236824,0.0005744521,0.00004798855,0.00007972835,0.0001944258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004992787,0.0001142628,0.2719288,0.0001073676,0.0001818804,0.001767846,0.0001709699,0.0001013331,0.7158721,0.0001103086,0.0001855022,0.004466855],"study_design_scores_gemma":[0.00002693054,0.0003278216,0.9743766,0.000003557115,0.00009583375,0.002907468,0.0001038144,0.0003456142,0.02140734,0.00006139469,0.0003341336,0.00000947022],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999273,0.0002949191,0.0001766955,0.00002539714,0.000004315313,0.000002178968,0.00006169541,0.00001348878,0.0001484166],"genre_scores_gemma":[0.9993935,0.000106684,0.0001058295,0.000008183734,0.000005139314,0.000002676416,0.000095012,0.000003613018,0.0002793989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727727,"threshold_uncertainty_score":0.005779862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170945904677257,"score_gpt":0.2859350482173591,"score_spread":0.2742255891705865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}