{"id":"W2012972567","doi":"10.1371/journal.pone.0109880","title":"Clinically Approved Iron Chelators Influence Zebrafish Mortality, Hatching Morphology and Cardiac Function","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; Canadian Blood Services; Michael Smith Health Research BC; University of Saskatchewan","keywords":"Deferiprone; Deferasirox; Embryo; Hatching; Zebrafish; Toxicity; Danio; Andrology; Biology; Developmental toxicity; Pharmacology; Chelation; Deferoxamine; Physiology; Chemistry; Internal medicine; Medicine; Pregnancy; Biochemistry; Cell biology; Animal science; Fetus; Thalassemia; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080483,0.0003612114,0.0003331419,0.0002545811,0.000227967,0.0002665607,0.0001624753,0.0004701992,0.001437064],"category_scores_gemma":[0.0002820736,0.0001612989,0.0002758206,0.00008807611,0.0002634487,0.0002105809,0.0002214954,0.0006803964,0.0002666598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005047625,"about_ca_system_score_gemma":0.0003976689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004176159,"about_ca_topic_score_gemma":0.009105373,"domain_scores_codex":[0.9998482,0.00001557623,0.00001634762,0.00003581418,0.00004985939,0.00003415348],"domain_scores_gemma":[0.9998285,0.00002266206,0.00005992282,0.000007517766,0.00004833544,0.00003295581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002119524,0.00003821287,0.001061822,0.00009589396,0.000007763668,0.00007251018,0.00005837235,0.00008282565,0.9961607,0.00003485186,0.0002438664,0.00193116],"study_design_scores_gemma":[0.00005141592,0.003201417,0.04603987,0.00005775612,0.0001230746,0.0002923371,0.000229097,0.001630211,0.9417238,0.00009068601,0.006520855,0.00003948426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901989,0.002951149,0.001340871,0.0002663149,0.00005532846,0.00008163216,0.0009793894,0.0001481259,0.003978298],"genre_scores_gemma":[0.98447,0.002801758,0.002783079,0.0002976572,0.00001543874,0.0001680114,0.001162467,0.00004107938,0.008260378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004176159,"threshold_uncertainty_score":0.008303702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137719871687937,"score_gpt":0.2460216701644208,"score_spread":0.2246444714475414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}