{"id":"W2013031612","doi":"10.1016/j.jmb.2003.09.034","title":"Pentamerization of Single-domain Antibodies from Phage Libraries: A Novel Strategy for the Rapid Generation of High-avidity Antibody Reagents","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"","keywords":"Avidity; Single-domain antibody; Phage display; Antigen; Antibody; Escherichia coli; Biology; Epitope; Molecular biology; Thermostability; Peptide library; Immunoglobulin light chain; Protein subunit; Chemistry; Monoclonal antibody; Computational biology; Biochemistry; Peptide sequence; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004324094,0.0001290436,0.0004656067,0.0001241599,0.00006294717,0.00001146931,0.0001495787,0.0001097296,0.0001156157],"category_scores_gemma":[0.0003354217,0.0000807562,0.0002164498,0.0001408887,0.0002708932,0.00007085885,0.00003002624,0.0001466975,6.067382e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001643857,"about_ca_system_score_gemma":0.000187344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000919703,"about_ca_topic_score_gemma":0.000003841931,"domain_scores_codex":[0.9986266,0.0001949007,0.0006226802,0.0001404056,0.0002382855,0.0001771067],"domain_scores_gemma":[0.9985816,0.0002568451,0.0005670633,0.0001674105,0.0003602909,0.00006680834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006123399,0.0003368944,0.003133929,0.00005450248,0.000422526,0.00001546886,0.0001009475,0.00006733913,0.987435,0.005408497,0.0001476686,0.002264858],"study_design_scores_gemma":[0.002239502,0.002413694,0.008572538,0.00007345557,0.0001780408,0.00008941289,0.0001823233,0.0002178201,0.981326,0.002212723,0.002403354,0.0000910836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8596116,0.002990358,0.1361383,0.0005430361,0.0002109779,0.0002519206,0.0001269997,0.000002339306,0.0001244232],"genre_scores_gemma":[0.9854513,0.0007040898,0.01326142,0.0001556311,0.0001878475,0.000002405633,0.0001885569,0.00001370184,0.00003501761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1258397,"threshold_uncertainty_score":0.3293142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08016236803364984,"score_gpt":0.3542359170636551,"score_spread":0.2740735490300053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}