{"id":"W2013046654","doi":"10.1016/j.cellimm.2012.01.004","title":"The activation, by antigen, of naïve TCR transgenic CD4 T cells cultured at physiological, rather than artificially high, frequencies more accurately reflects the in vivo activation of normal numbers of naïve CD4+ T cells","year":2012,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; T-cell receptor; Molecular biology; Cell biology; In vivo; T cell; Population; CD80; CD40; In vitro; Immunology; Cytotoxic T cell; Immune system; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008926378,0.0007746927,0.0005952675,0.0004628634,0.0002873301,0.001144733,0.0003229835,0.0007541472,0.00159551],"category_scores_gemma":[0.0009537979,0.0002858369,0.0001869115,0.0004145537,0.0007209641,0.0008054547,0.0003371345,0.002564364,0.0005089997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410631,"about_ca_system_score_gemma":0.0002420491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002360798,"about_ca_topic_score_gemma":0.0003297576,"domain_scores_codex":[0.9986743,0.0004843132,0.0001768934,0.0002714543,0.0002569756,0.0001360441],"domain_scores_gemma":[0.9992056,0.0004379276,0.00006790208,0.0001801629,0.00004216477,0.00006620021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002631768,0.0001298862,0.0009392501,0.00004809853,0.000005865889,0.00003174422,0.00005271723,0.0002088382,0.996639,0.0002420307,0.00004976438,0.001389719],"study_design_scores_gemma":[0.00001862399,0.0003583496,0.001953159,0.000004774423,0.00001886298,0.0001522612,0.00002771185,0.001979555,0.9945713,0.0001430524,0.0007686326,0.000003809912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739996,0.0008777895,0.02172387,0.0001202894,0.0001432951,0.00004703561,0.000301354,0.0001984979,0.002588277],"genre_scores_gemma":[0.9835746,0.0005389387,0.01266975,0.0001143977,0.00007067429,0.0001437716,0.0007795431,0.0001093498,0.001998854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159551,"threshold_uncertainty_score":0.005337477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038695446152873,"score_gpt":0.3019408328044642,"score_spread":0.2615538783429355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}