{"id":"W2013084027","doi":"10.1074/jbc.c800170200","title":"Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute","keywords":"mTORC2; mTORC1; PI3K/AKT/mTOR pathway; Cancer research; Biology; Protein kinase B; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138282,0.000176829,0.0002975988,0.00002055577,0.00005755377,0.000009330252,0.0001933144,0.0003129258,0.0000702359],"category_scores_gemma":[0.0002089649,0.0001225624,0.0001102176,0.00004224664,0.0002891771,0.000004939373,0.00009843146,0.000238298,3.537588e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001439691,"about_ca_system_score_gemma":0.00006375238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003318499,"about_ca_topic_score_gemma":2.258349e-7,"domain_scores_codex":[0.9990024,0.00003437329,0.0003470753,0.0002540949,0.0001796247,0.0001824361],"domain_scores_gemma":[0.9992148,0.00005725825,0.0003084851,0.000163404,0.0001029572,0.0001531169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001981588,0.00007304054,0.0295799,0.00002380039,0.00005228466,0.0000161988,0.00002048876,0.000006802256,0.9695179,0.00000307674,0.000217098,0.0002912531],"study_design_scores_gemma":[0.0005130765,0.0006488555,0.02113158,0.00003712433,0.00001585459,0.0002426869,0.00003812693,0.00000274992,0.9760804,0.00003810657,0.001107503,0.0001439927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981165,0.001219822,0.0001877824,0.0000285752,0.00009660879,0.00003605467,0.00001707634,0.000004085353,0.0002934775],"genre_scores_gemma":[0.9984215,0.000861711,0.0002232152,0.00004237676,0.0003400898,0.0000011539,0.000007562712,0.000009593428,0.00009277913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008448319,"threshold_uncertainty_score":0.499795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03519021538862276,"score_gpt":0.2598802829788023,"score_spread":0.2246900675901796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}