{"id":"W2013088336","doi":"10.1021/ja0482076","title":"Synthesis of Alkylated Deoxynojirimycin and 1,5-Dideoxy-1,5-iminoxylitol Analogues:  Polar Side-Chain Modification, Sulfonium and Selenonium Heteroatom Variants, Conformational Analysis, and Evaluation as Glycosidase Inhibitors","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Sulfonium; Heteroatom; Side chain; Alkylation; Stereochemistry; Glycoside hydrolase; Biochemistry; Organic chemistry; Enzyme; Ring (chemistry); Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007794122,0.0002606972,0.0006665995,0.00006705351,0.0001508553,0.00006798765,0.0002369681,0.0001665728,0.00003256502],"category_scores_gemma":[0.0006065132,0.0002036757,0.0004007184,0.0005690472,0.0007428339,0.0002229138,0.0001108583,0.0003753942,4.085454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352205,"about_ca_system_score_gemma":0.0002270117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003590331,"about_ca_topic_score_gemma":0.000004052389,"domain_scores_codex":[0.9978681,0.00007867253,0.0008804029,0.0002810195,0.0006514995,0.0002403303],"domain_scores_gemma":[0.9972233,0.0004584907,0.001387871,0.000296868,0.0004181495,0.000215349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168052,0.000103782,0.003681007,0.0001031404,0.0009868697,0.000001482312,0.0007774618,0.000232846,0.9924483,0.00002266175,0.0000605619,0.001465056],"study_design_scores_gemma":[0.0007434624,0.00002461085,0.006164999,0.000119493,0.001540234,0.0001486819,0.001538355,0.002685567,0.9862549,0.0005184365,0.00003441372,0.0002267905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980702,0.0004830053,0.0001091274,0.001022774,0.00002072669,0.00007948576,0.00008605814,0.00001232235,0.0001163306],"genre_scores_gemma":[0.9984178,0.0003826403,0.0008967472,0.0001446067,0.0001040561,0.000007428498,0.00002260352,0.0000165492,0.000007593137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00619337,"threshold_uncertainty_score":0.8305653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055056642457703,"score_gpt":0.246498970226858,"score_spread":0.235948403802281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}