{"id":"W2013088336","doi":"10.1021/ja0482076","title":"Synthesis of Alkylated Deoxynojirimycin and 1,5-Dideoxy-1,5-iminoxylitol Analogues:  Polar Side-Chain Modification, Sulfonium and Selenonium Heteroatom Variants, Conformational Analysis, and Evaluation as Glycosidase Inhibitors","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Sulfonium; Heteroatom; Side chain; Alkylation; Stereochemistry; Glycoside hydrolase; Biochemistry; Organic chemistry; Enzyme; Ring (chemistry); Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092625,0.0003122095,0.0003234828,0.0001651766,0.0001035711,0.0002125914,0.0002290282,0.0002196857,0.000635075],"category_scores_gemma":[0.0001407777,0.0001131951,0.0001314588,0.0002769925,0.0001573234,0.000161503,0.0001224254,0.0003376094,0.000319164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854529,"about_ca_system_score_gemma":0.00026873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003617175,"about_ca_topic_score_gemma":0.0007643274,"domain_scores_codex":[0.9999243,0.00001314241,0.00001229744,0.00001442567,0.00001818175,0.00001760106],"domain_scores_gemma":[0.9998889,0.000012172,0.0000313608,0.00001610869,0.00002029447,0.00003114109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009962273,0.00002439219,0.0000940666,0.00003824924,0.000004476296,0.00006965746,0.00001745827,0.0002787949,0.9952124,0.0001208647,0.00002431295,0.004015555],"study_design_scores_gemma":[0.00002916648,0.0004230518,0.0008216448,0.000003237186,0.00001263587,0.0001085877,0.000008883982,0.0002635018,0.995039,0.00002225268,0.003262601,0.000005334485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988386,0.002104769,0.00551891,0.00006723405,0.00004828069,0.0001099797,0.0004757246,0.00006614764,0.003222879],"genre_scores_gemma":[0.9833764,0.00176434,0.01075045,0.00006713453,0.00001744914,0.00009439394,0.000891781,0.00003748835,0.00300056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000635075,"threshold_uncertainty_score":0.002124608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055056642457703,"score_gpt":0.246498970226858,"score_spread":0.235948403802281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}