{"id":"W2013132275","doi":"10.3747/co.19.1011","title":"Bone-Targeted Agents and Skeletal-Related Events in Breast Cancer Patients with Bone Metastases: The State of the Art","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bone health and treatments","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; University of British Columbia; Ottawa Regional Cancer Foundation","funders":"Amgen","keywords":"Denosumab; Medicine; Breast cancer; Oncology; Bone resorption; Cancer; RANKL; Spinal cord compression; Internal medicine; Osteoclast; Teriparatide; Osteonecrosis of the jaw; Osteoporosis; Bisphosphonate; Bone mineral; Activator (genetics); Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002496148,0.0001677817,0.0003964163,0.00007586421,0.00007005897,0.000001626213,0.00006108284,0.00005846746,0.00009276297],"category_scores_gemma":[0.00002290133,0.00008172046,0.00005245988,0.0002786178,0.000152758,0.00007675696,0.00006716549,0.0002846256,0.00001697552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978867,"about_ca_system_score_gemma":0.0001912116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000184613,"about_ca_topic_score_gemma":0.0002006107,"domain_scores_codex":[0.9985374,0.0002247115,0.0003861819,0.0001799599,0.0002473889,0.0004243791],"domain_scores_gemma":[0.9991677,0.00006074698,0.0002677425,0.0002255033,0.00009065404,0.0001876183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003827188,0.001999126,0.9586361,0.00008399376,0.0001197326,0.000003025268,0.000554239,0.000001637067,0.000007306069,0.000006593682,0.0009720167,0.03723348],"study_design_scores_gemma":[0.006827666,0.0002612817,0.9805493,0.0001558937,0.0002372659,0.00003258626,0.00002751358,0.00002632193,0.00001836992,0.00003059045,0.01176019,0.00007304933],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932995,0.003211198,0.000001130684,0.001445803,0.0007075349,0.001074199,0.0001586288,0.00001002634,0.00009190989],"genre_scores_gemma":[0.9989572,0.0004010817,0.00001380255,0.0002536107,0.00001874378,0.0001096794,0.00007462365,0.00001661878,0.0001546902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03716043,"threshold_uncertainty_score":0.3332464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317372013363539,"score_gpt":0.3541878627922111,"score_spread":0.3210141426585757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}