{"id":"W2013146296","doi":"10.1002/jat.1225","title":"Evaluation of physiologically based pharmacokinetic models for use in risk assessment","year":2007,"lang":"en","type":"review","venue":"Journal of Applied Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Computer science; Flexibility (engineering); Risk assessment; Mathematical model; Representation (politics); Model selection; Risk analysis (engineering); Relevance (law); Model validation; Biochemical engineering; Machine learning; Data science; Engineering; Bioinformatics; Statistics; Biology; Medicine; Mathematics; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00294826,0.001724215,0.0024404,0.00300474,0.0003497124,0.001699301,0.002554585,0.002056921,0.00332015],"category_scores_gemma":[0.004242818,0.000624988,0.001246444,0.002237529,0.0008626399,0.002074063,0.0007640888,0.002167441,0.00309026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001503762,"about_ca_system_score_gemma":0.001415557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530518,"about_ca_topic_score_gemma":0.001069242,"domain_scores_codex":[0.9989359,0.0003068616,0.0001097571,0.0001286843,0.0004865613,0.00003218568],"domain_scores_gemma":[0.9977726,0.001418009,0.0001808008,0.000102215,0.0004829836,0.00004323963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00006717583,0.0001471093,0.0004688104,0.01346066,0.0002016029,0.0005866312,0.0001449753,0.03569804,0.006651867,0.05043334,0.01833389,0.8738059],"study_design_scores_gemma":[0.00003423995,0.0002729801,0.0008392935,0.00456671,0.000316184,0.002010163,0.000131186,0.01947313,0.007960562,0.03967923,0.9245927,0.0001234825],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001537104,0.8813013,0.0999185,0.001439233,0.0007205572,0.0001328421,0.0001885253,0.0002842784,0.01447763],"genre_scores_gemma":[0.01323966,0.9278004,0.05355783,0.0004385463,0.0004090396,0.0001944101,0.0002846945,0.00005071509,0.004024592],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00332015,"threshold_uncertainty_score":0.01559204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1446043919041057,"score_gpt":0.4298466842709888,"score_spread":0.2852422923668831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}