{"id":"W2013158844","doi":"10.1126/science.1162790","title":"Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase","year":2008,"lang":"en","type":"article","venue":"Science","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":446,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Ubiquitin; Ubiquitin ligase; DNA ligase; DNA damage; Cell biology; DNA repair; Computational biology; Chemistry; DNA; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305803,0.00008144701,0.00007212428,0.00005671594,0.0002012439,0.00001176859,0.0002377049,0.00003448659,0.0000389485],"category_scores_gemma":[0.0001877712,0.00008253213,0.00003416902,0.0002532807,0.0002141959,0.000004291992,0.0002208905,0.00004033704,0.00001801168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001474289,"about_ca_system_score_gemma":0.0001541839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009698455,"about_ca_topic_score_gemma":0.00001100952,"domain_scores_codex":[0.9989992,0.00001485609,0.000147737,0.0003119062,0.0002911763,0.0002350961],"domain_scores_gemma":[0.9995751,0.000003639002,0.00005659157,0.0001457737,0.0001111344,0.0001076954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001462161,0.00005262578,0.001833785,0.000002110099,0.000003374515,0.000003904237,0.0001106859,0.0001034575,0.9964036,0.00001642823,0.001347864,0.0001074934],"study_design_scores_gemma":[0.0002237164,0.0001791044,0.2089597,0.000006103813,0.000002192888,0.000008302403,0.0001502539,0.00004060347,0.7881689,0.00001919234,0.002110559,0.0001314246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984846,0.00003632601,0.00004606903,0.0001169506,0.0001206941,0.00008251398,0.00001164516,0.00000743971,0.001093796],"genre_scores_gemma":[0.998638,0.00003137208,0.0005073951,0.0004088971,0.0000107496,0.000003117259,0.00002139369,0.000009440649,0.0003695731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2082348,"threshold_uncertainty_score":0.3365563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250570380094514,"score_gpt":0.220860127488615,"score_spread":0.2083544236876698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}