{"id":"W2013164746","doi":"10.3390/molecules19021576","title":"Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells","year":2014,"lang":"en","type":"article","venue":"Molecules","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Reactive oxygen species; Glutathione; Mitochondrial ROS; Cytoprotection; Mitochondrion; Menadione; Biochemistry; Antioxidant; Oxidative stress; Glutathione reductase; Chemistry; Oxidative phosphorylation; Biology; Cell biology; Pharmacology; Glutathione peroxidase; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000151261,0.0004919961,0.0006275367,0.0003163419,0.0002767834,0.0001886224,0.0002109416,0.0003364323,0.0006539286],"category_scores_gemma":[0.00009162496,0.0001358748,0.0004056121,0.0003113772,0.0001766757,0.0002187564,0.0002977188,0.0005225026,0.0001606956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290529,"about_ca_system_score_gemma":0.000352111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085031,"about_ca_topic_score_gemma":0.003868286,"domain_scores_codex":[0.9999125,0.00001154206,0.0000117129,0.00001637791,0.00001927024,0.00002858784],"domain_scores_gemma":[0.9999392,0.000006240792,0.00001289326,0.000008724214,0.000009407574,0.00002354621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003822605,0.00005005739,0.0001602821,0.00006218968,0.00001215631,0.0000607098,0.00002823847,0.00002998997,0.9983587,0.00001626251,0.00002060653,0.0008185973],"study_design_scores_gemma":[0.00007048835,0.001063806,0.01229166,0.00001057936,0.00005232068,0.000182466,0.00005841393,0.0004215859,0.984355,0.00002573322,0.001459939,0.000007941298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994963,0.003265593,0.0007328393,0.00009039546,0.00003189666,0.00002960268,0.000204847,0.00004769443,0.0006341179],"genre_scores_gemma":[0.9950144,0.001828248,0.001071381,0.00007649707,0.00002092421,0.00004511972,0.0005538571,0.0000103723,0.00137922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085031,"threshold_uncertainty_score":0.004145801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0322870884604823,"score_gpt":0.2619657795327709,"score_spread":0.2296786910722886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}