{"id":"W2013166769","doi":"10.1091/mbc.e05-10-0991","title":"Ran Is Required before Metaphase for Spindle Assembly and Chromosome Alignment and after Metaphase for Chromosome Segregation and Spindle Midbody Organization","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation","keywords":"Ran; Biology; Cell biology; Mitosis; Metaphase; Spindle checkpoint; Midbody; Multipolar spindles; Spindle apparatus; Aurora B kinase; Spindle pole body; Chromosome segregation; PLK1; Polo-like kinase; Anaphase; Kinesin; Centrosome; Microtubule; Genetics; Cell cycle; Cell division; Chromosome; Cytokinesis; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001211179,0.0003495819,0.0002284185,0.000296212,0.0004254753,0.0005392116,0.0002638809,0.0003115551,0.001806367],"category_scores_gemma":[0.0002729277,0.0003650237,0.0001780992,0.0001200377,0.0002540476,0.0003599117,0.00029104,0.0003517436,0.001261201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004506479,"about_ca_system_score_gemma":0.0003117806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370249,"about_ca_topic_score_gemma":0.00415951,"domain_scores_codex":[0.9998461,0.00001608202,0.00001382696,0.00004225547,0.00004897566,0.00003277195],"domain_scores_gemma":[0.9997453,0.00003560372,0.00008453768,0.00002445979,0.00005148377,0.0000585843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379109,0.00001000721,0.0004867833,0.00002831101,0.00000411015,0.0002017558,0.00001252691,0.00006695221,0.9971249,0.0002856849,0.00005954421,0.001581494],"study_design_scores_gemma":[0.00004961182,0.0002028115,0.05953477,0.00002449166,0.00003352741,0.001679179,0.00006651222,0.002562413,0.9203458,0.0004514625,0.01502715,0.00002224787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763168,0.006891322,0.008036032,0.0001728065,0.00006058954,0.0000378018,0.001009733,0.0004010652,0.007073976],"genre_scores_gemma":[0.9853771,0.001170011,0.003727908,0.00004174565,0.00001546087,0.00002863596,0.002415038,0.00006871002,0.007155338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806367,"threshold_uncertainty_score":0.006042957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004310557991310332,"score_gpt":0.2284591276654977,"score_spread":0.2241485696741873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}