{"id":"W2013166769","doi":"10.1091/mbc.e05-10-0991","title":"Ran Is Required before Metaphase for Spindle Assembly and Chromosome Alignment and after Metaphase for Chromosome Segregation and Spindle Midbody Organization","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation","keywords":"Ran; Biology; Cell biology; Mitosis; Metaphase; Spindle checkpoint; Midbody; Multipolar spindles; Spindle apparatus; Aurora B kinase; Spindle pole body; Chromosome segregation; PLK1; Polo-like kinase; Anaphase; Kinesin; Centrosome; Microtubule; Genetics; Cell cycle; Cell division; Chromosome; Cytokinesis; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682056,0.0002145982,0.000254243,0.00004900622,0.0001216775,0.0000213432,0.0001176247,0.0002494073,0.000003689398],"category_scores_gemma":[0.00003926738,0.000172447,0.00009914164,0.00007652374,0.0001896165,0.000008091701,0.0001282491,0.00003986015,2.723148e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001237279,"about_ca_system_score_gemma":0.00003381104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002576357,"about_ca_topic_score_gemma":0.00003249213,"domain_scores_codex":[0.9989511,0.00005866856,0.0002697309,0.0004401304,0.00005482899,0.0002255768],"domain_scores_gemma":[0.9993491,0.00001295088,0.0001781161,0.0002939522,0.0001141129,0.00005180212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007960844,0.00008577089,0.001367268,0.0001112375,0.00008818049,6.491093e-7,0.00006276808,0.000004128772,0.9974979,0.0002339833,0.0001301398,0.0003383515],"study_design_scores_gemma":[0.001940306,0.0005953155,0.0006090071,0.0000151943,0.0002211956,0.00001598326,0.00002667638,0.0001793366,0.9924145,0.001253494,0.002540936,0.0001880797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785997,0.003336589,0.01645556,0.0003440925,0.00007846151,0.0009190908,0.0002465579,0.000006310841,0.00001360645],"genre_scores_gemma":[0.9950584,0.0001321233,0.003487807,0.0003729008,0.00005866923,0.00008496257,0.000519502,0.00003536092,0.0002502615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01645868,"threshold_uncertainty_score":0.7032183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004310557991310332,"score_gpt":0.2284591276654977,"score_spread":0.2241485696741873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}