{"id":"W2013169261","doi":"10.1074/jbc.m700326200","title":"Differential Regulation of ATP Binding Cassette Protein A1 Expression and ApoA-I Lipidation by Niemann-Pick Type C1 in Murine Hepatocytes and Macrophages","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; NPC1; Biology; ATP Binding Cassette Transporter 1; Lipid-anchored protein; ABCG1; Cholesterol; Biochemistry; Cell biology; Molecular biology; Endosome; Autophagy; Gene; Cell; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020649,0.0002900245,0.0003024098,0.0004675887,0.000172945,0.0003321815,0.0001593208,0.0003143327,0.0005417792],"category_scores_gemma":[0.0001608245,0.0002713763,0.0002952064,0.0002101494,0.0002871608,0.0001806693,0.0002538617,0.0004479877,0.0004523702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351215,"about_ca_system_score_gemma":0.0001720484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008113269,"about_ca_topic_score_gemma":0.0007421884,"domain_scores_codex":[0.9997423,0.00004614354,0.00003368762,0.00005013814,0.00005978382,0.00006781369],"domain_scores_gemma":[0.9997332,0.00004252809,0.00007955014,0.00003593554,0.00004018063,0.00006873837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002394792,0.0000172512,0.0002485214,0.00002172084,0.000003541835,0.00004590529,0.00002144834,0.00004930549,0.9988502,0.00007372598,0.00001700543,0.0004118218],"study_design_scores_gemma":[0.00003167484,0.0002417902,0.008010636,0.000005491918,0.00001965989,0.000188996,0.00004927374,0.0009160346,0.9893807,0.00006089737,0.001082171,0.00001260839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961358,0.001433135,0.001174093,0.00005866359,0.0000191429,0.00001606944,0.0004266107,0.00005827972,0.0006781904],"genre_scores_gemma":[0.9936387,0.0009658595,0.002200678,0.00005793366,0.00001261953,0.00009130243,0.0005927102,0.00004468611,0.002395429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008113269,"threshold_uncertainty_score":0.002548277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02293760302307953,"score_gpt":0.2965612622309635,"score_spread":0.273623659207884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}