{"id":"W2013207372","doi":"10.1042/bj20090268","title":"Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4","year":2009,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Agence Nationale pour la Gestion des Déchets Radioactifs; University of British Columbia","keywords":"Methylation; Chemistry; Methyltransferase; Arginine; Enzyme; Asymmetric dimethylarginine; Biochemistry; Histone; High-performance liquid chromatography; Stereochemistry; Chromatography; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003481814,0.0001808848,0.0003853103,0.0006650009,0.00005598123,0.0000140464,0.0001439212,0.0002098462,0.00001973429],"category_scores_gemma":[0.0001559297,0.0001677103,0.0002155501,0.000856786,0.0001048862,0.00001042851,0.00002215709,0.000188053,4.259836e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004899607,"about_ca_system_score_gemma":0.00003665136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001281803,"about_ca_topic_score_gemma":0.000003365481,"domain_scores_codex":[0.9985554,0.00009040128,0.0006290263,0.0002500592,0.0002837542,0.0001914128],"domain_scores_gemma":[0.9990471,0.00002324501,0.0003561444,0.0002568862,0.000187731,0.0001288696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002834472,0.0001432935,0.0001877026,0.00002137482,0.0002250707,0.000001077549,0.00004591408,0.0003061753,0.9901363,0.00004804025,0.0002063738,0.008395214],"study_design_scores_gemma":[0.0009499592,0.001245469,0.01795964,0.00005388971,0.0003795804,0.00001345408,0.00001979032,0.0002588468,0.9786742,0.0001476016,0.0001315609,0.0001659863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933376,0.00338792,0.002612844,0.0002467994,0.00002875942,0.0001818982,0.00002374047,0.000006164499,0.000174285],"genre_scores_gemma":[0.9980342,0.0003349997,0.001239264,0.00003101589,0.0001341775,0.000004181308,0.0001485733,0.00001231958,0.00006128374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01777194,"threshold_uncertainty_score":0.6839029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009096538361155244,"score_gpt":0.2770195158509192,"score_spread":0.2679229774897639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}