{"id":"W2013272034","doi":"10.1021/bi802206k","title":"Interaction of Bupropion with Muscle-Type Nicotinic Acetylcholine Receptors in Different Conformational States","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute on Drug Abuse; Agencia Nacional de Promoción Científica y Tecnológica; Science Foundation Arizona; Consejo Nacional de Investigaciones Científicas y Técnicas; Fundacja na rzecz Nauki Polskiej; Midwestern University; National Institutes of Health","keywords":"Chemistry; Nicotinic agonist; Biophysics; Acetylcholine receptor; Allosteric regulation; Nicotinic acetylcholine receptor; Bupropion; Acetylcholine; Neuromuscular junction; Stereochemistry; Receptor; Endocrinology; Biochemistry; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120037,0.0002246491,0.0002301166,0.00004951271,0.00002899622,0.00001234596,0.000190298,0.0001695846,0.00006898627],"category_scores_gemma":[0.00009205123,0.0001813231,0.00006582941,0.0001578355,0.00006801463,0.000009555673,0.00005809531,0.0001787436,0.000005540065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005100594,"about_ca_system_score_gemma":0.00008986711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009048444,"about_ca_topic_score_gemma":0.00001096499,"domain_scores_codex":[0.9987938,0.00003168231,0.000417469,0.000322628,0.0002013476,0.0002330637],"domain_scores_gemma":[0.9992076,0.00001661311,0.0002289449,0.0003234349,0.0001506026,0.00007280823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000445618,0.0004298927,0.009915903,0.00004687876,0.00003867765,2.330641e-7,0.0000978288,0.0001366847,0.9833988,0.000007617206,0.001963047,0.003518842],"study_design_scores_gemma":[0.001267141,0.0005457497,0.005916285,0.00007468779,0.00001526606,0.00001148115,0.0003378193,0.0001069711,0.9879152,0.000009519898,0.003564179,0.0002357641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984719,0.0002185739,0.0001018253,0.0002066528,0.0001453999,0.0001825115,0.00001315402,0.00001630152,0.0006436967],"genre_scores_gemma":[0.9980816,0.0002322211,0.0003585617,0.00009855879,0.0001979255,0.000008288522,0.0006512576,0.00001592426,0.0003557071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004516359,"threshold_uncertainty_score":0.7394142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007684627729342891,"score_gpt":0.2582829638613722,"score_spread":0.2505983361320293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}