{"id":"W2013284852","doi":"10.1021/jm100089e","title":"Design and Synthesis of α-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis","year":2010,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Angiogenesis; Chemistry; Cathepsin; Metastasis; Cathepsin D; Cancer research; Proteolytic enzymes; Cathepsin S; Enzyme; Biochemistry; Cancer; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176297,0.0005660512,0.0003755895,0.0002454313,0.0001462258,0.0002873109,0.000391149,0.0003463822,0.001299273],"category_scores_gemma":[0.0002115468,0.0002021645,0.0002367914,0.0002459555,0.0002389571,0.0004093334,0.0002157029,0.0004458119,0.0003534112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283672,"about_ca_system_score_gemma":0.0003951555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003614,"about_ca_topic_score_gemma":0.000795686,"domain_scores_codex":[0.9999182,0.00001490281,0.00001163011,0.00001375601,0.00001933719,0.00002215479],"domain_scores_gemma":[0.9998982,0.00001395766,0.0000337318,0.000006097288,0.00001738603,0.00003056105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000660472,0.0002218833,0.0002215475,0.0005339282,0.00003644703,0.0006091913,0.00009378327,0.002952819,0.9651137,0.00230879,0.000371491,0.02687582],"study_design_scores_gemma":[0.0004259433,0.004447396,0.001160551,0.0000511597,0.00008124821,0.0009640389,0.00005231141,0.002213172,0.9653823,0.0004431336,0.02473142,0.00004737295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291018,0.02627186,0.03124464,0.000456586,0.0002302919,0.001009456,0.001021124,0.0002041916,0.01046009],"genre_scores_gemma":[0.9566349,0.01670396,0.02129621,0.0001653506,0.000051086,0.0003535667,0.000602858,0.00001625869,0.004175804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299273,"threshold_uncertainty_score":0.00434649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003936506251334944,"score_gpt":0.2030994241514898,"score_spread":0.1991629179001548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}