{"id":"W2013308243","doi":"10.1002/iub.187","title":"GSK‐3: A key player in neurodegeneration and memory","year":2009,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Alzheimer's Research Trust; Alzheimer Society; Wellcome Trust","keywords":"Neurodegeneration; GSK-3; Neuroscience; Hyperphosphorylation; Long-term potentiation; Cyclin-dependent kinase 5; Biology; Cell biology; Kinase; Chemistry; Protein kinase A; Medicine; Disease; Biochemistry; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319708,0.0003020198,0.001039593,0.0002638061,0.00004295469,0.00003400167,0.00006646662,0.0001929298,0.00007486507],"category_scores_gemma":[0.0001304825,0.0002244,0.0001746145,0.0002238463,0.00003807844,0.00006816325,0.00003873727,0.0003299913,0.0001854667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008998036,"about_ca_system_score_gemma":0.0007561729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000332623,"about_ca_topic_score_gemma":0.00001315294,"domain_scores_codex":[0.9984211,0.0001510838,0.0003661531,0.0004148157,0.0003299775,0.000316853],"domain_scores_gemma":[0.9989931,0.00006892562,0.00008958935,0.0003181053,0.00003745312,0.0004928307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006610384,0.0003548923,0.0001891806,0.004085496,0.001629474,0.0008983799,0.00003025152,3.53946e-7,1.747068e-7,0.0000426849,0.003327711,0.9893753],"study_design_scores_gemma":[0.002660785,0.0004700086,0.001653143,0.008300701,0.003463868,0.0002250514,0.000009904737,0.0000289435,0.000002719428,0.00004234942,0.9826984,0.0004441031],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000423875,0.9962305,0.000001080828,0.0001480159,0.00005622937,0.001098634,0.00003624099,0.00003414705,0.001971222],"genre_scores_gemma":[0.0007356106,0.9978971,0.00006282147,0.000312492,0.0003237729,0.0001222234,0.0002966396,0.00004025506,0.0002090304],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9889312,"threshold_uncertainty_score":0.9150767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08323079412608174,"score_gpt":0.3829624640397941,"score_spread":0.2997316699137123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}