{"id":"W2013380575","doi":"10.1371/journal.pone.0015666","title":"Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"Microsome; Verapamil; Messenger RNA; Pharmacology; Drug metabolism; CYP2C9; Biology; Drug; Cytochrome P450; Heart failure; Internal medicine; Endocrinology; Medicine; Metabolism; Enzyme; Biochemistry; Gene; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002395987,0.0001546277,0.0001676783,0.0003903433,0.0001407395,0.0003311946,0.00006700242,0.0001660871,0.001583109],"category_scores_gemma":[0.0004521915,0.00009934485,0.0001402454,0.0002725883,0.0001823087,0.00009392262,0.00009100793,0.0002243231,0.000421182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120038,"about_ca_system_score_gemma":0.00009467237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003670816,"about_ca_topic_score_gemma":0.0003972657,"domain_scores_codex":[0.9997799,0.0000431822,0.00001782262,0.00008370091,0.00004271271,0.00003264606],"domain_scores_gemma":[0.9996672,0.0001129543,0.00008027021,0.00003598413,0.00007513963,0.0000283447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008610421,0.00007230966,0.08739927,0.00008814645,0.00007426924,0.0002358544,0.0001936421,0.0001110449,0.8984952,0.00008257061,0.0001587464,0.01222793],"study_design_scores_gemma":[0.00004472728,0.00109883,0.7497371,0.00001468498,0.0001597059,0.001995085,0.0001564316,0.000710776,0.2434373,0.0001254458,0.002508338,0.00001161691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954326,0.001311907,0.00144379,0.00003203114,0.000007520094,0.00002049848,0.000850521,0.00001854121,0.0008826986],"genre_scores_gemma":[0.994867,0.000518095,0.001610228,0.00002829773,0.00003157442,0.0000431791,0.002063558,0.00001137543,0.0008267147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583109,"threshold_uncertainty_score":0.005295992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1483424139745386,"score_gpt":0.3868598384239944,"score_spread":0.2385174244494557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}