{"id":"W2013380575","doi":"10.1371/journal.pone.0015666","title":"Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"Microsome; Verapamil; Messenger RNA; Pharmacology; Drug metabolism; CYP2C9; Biology; Drug; Cytochrome P450; Heart failure; Internal medicine; Endocrinology; Medicine; Metabolism; Enzyme; Biochemistry; Gene; Calcium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001463689,0.0003253765,0.0009589888,0.0003010184,0.0001607455,0.00002015591,0.0003518052,0.0003286219,0.000596082],"category_scores_gemma":[0.0001251305,0.0003313087,0.000132783,0.000346705,0.0003551122,0.0001823694,0.0002237087,0.001564201,0.00002499995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001030769,"about_ca_system_score_gemma":0.00008279367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002019666,"about_ca_topic_score_gemma":0.0002210034,"domain_scores_codex":[0.9975915,0.0006082038,0.0004774527,0.0004510747,0.0003310394,0.000540733],"domain_scores_gemma":[0.998628,0.0002781815,0.0002334438,0.00036642,0.0001496941,0.0003442563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000826086,0.001747205,0.02544053,0.00008587819,0.0005621591,0.000005962543,0.0008681093,0.000002769179,0.9615576,0.004079677,0.0000714447,0.005496023],"study_design_scores_gemma":[0.001740542,0.00001553866,0.1554417,0.00001246074,0.000754909,6.040447e-7,0.0000316698,0.000241282,0.8326175,0.001271306,0.007582926,0.000289509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903437,0.005002223,0.000001527519,0.0004116908,0.0006676428,0.0005643563,0.0002934435,0.00005242769,0.002662935],"genre_scores_gemma":[0.9963788,0.001638263,0.0006359051,0.0004132502,0.0004510653,0.00007746953,0.000009074546,0.00004361974,0.0003526012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1300012,"threshold_uncertainty_score":0.9999139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1483424139745386,"score_gpt":0.3868598384239944,"score_spread":0.2385174244494557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}