{"id":"W2013409259","doi":"10.1016/j.humimm.2013.05.010","title":"HLA-DO increases bacterial superantigen binding to human MHC molecules by inhibiting dissociation of class II-associated invariant chain peptides","year":2013,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; Hôpital Saint-Luc; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Human leukocyte antigen; Superantigen; MHC class II; Major histocompatibility complex; Peptide; Biology; MHC class I; MHC restriction; Molecular biology; CIITA; T-cell receptor; Chemistry; HLA-DR; Cell biology; Antigen; Immunology; T cell; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006044912,0.0003225502,0.0006232895,0.0004161593,0.000975418,0.00005941986,0.0003608594,0.0005486051,0.001618202],"category_scores_gemma":[0.000531599,0.0003307697,0.0001504073,0.0002416113,0.0002661281,0.0003167423,0.0003106838,0.0003462504,0.0004541867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773097,"about_ca_system_score_gemma":0.00006077292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592823,"about_ca_topic_score_gemma":0.000120162,"domain_scores_codex":[0.9970524,0.0008972915,0.0009220792,0.0003985018,0.00007324764,0.0006565301],"domain_scores_gemma":[0.9986928,0.0002076698,0.0005245372,0.0003108911,0.0002347092,0.00002942659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143242,0.0002383248,0.001398517,0.0000130888,0.0003942443,0.000001792765,0.001986817,0.000001360752,0.9900023,0.001919003,0.003332089,0.0005692022],"study_design_scores_gemma":[0.002263674,0.0008763234,0.04887009,0.0001721128,0.00006184058,0.00001574446,0.001278207,0.000002884556,0.9432943,0.0002633416,0.002465052,0.0004364526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973103,0.0008151299,0.00001433794,0.0002695321,0.0002733498,0.0006043556,0.00005849914,0.0001226872,0.0005317705],"genre_scores_gemma":[0.9960696,0.00005833116,0.00001876917,0.00007498371,0.0000444806,0.0001114016,0.001916296,0.0000427939,0.001663313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04747158,"threshold_uncertainty_score":0.9999144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009183651940097421,"score_gpt":0.2254598991905835,"score_spread":0.2162762472504861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}