{"id":"W2013409259","doi":"10.1016/j.humimm.2013.05.010","title":"HLA-DO increases bacterial superantigen binding to human MHC molecules by inhibiting dissociation of class II-associated invariant chain peptides","year":2013,"lang":"en","type":"article","venue":"Human Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital; Hôpital Saint-Luc; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Human leukocyte antigen; Superantigen; MHC class II; Major histocompatibility complex; Peptide; Biology; MHC class I; MHC restriction; Molecular biology; CIITA; T-cell receptor; Chemistry; HLA-DR; Cell biology; Antigen; Immunology; T cell; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662515,0.000308709,0.0002696056,0.0001484657,0.0001765516,0.0003985946,0.0002286466,0.0002570701,0.004381979],"category_scores_gemma":[0.0003338887,0.0001921861,0.0001386593,0.0000881314,0.0002710406,0.0001753586,0.000222301,0.0008643965,0.0007634308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235046,"about_ca_system_score_gemma":0.0002223557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854412,"about_ca_topic_score_gemma":0.0005134996,"domain_scores_codex":[0.9998216,0.00003630013,0.00001323303,0.00002785235,0.00002342492,0.00007759744],"domain_scores_gemma":[0.9997353,0.00007774741,0.00004584823,0.00003802543,0.00001171885,0.0000913621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001571677,0.0007748944,0.0006897814,0.00003841112,0.00001934838,0.0000602466,0.00002154506,0.00005787011,0.9923196,0.0001691262,0.0002267591,0.004050612],"study_design_scores_gemma":[0.0003351497,0.00334185,0.01436986,0.00000872281,0.0000396769,0.0004004967,0.00008685932,0.0006459717,0.9771327,0.0001542113,0.003475927,0.000008567566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996256,0.0005968779,0.0006743733,0.0001583037,0.00007796186,0.00001934436,0.0001169978,0.00006421867,0.002036102],"genre_scores_gemma":[0.9960758,0.0004245885,0.0005249045,0.0001457188,0.0000689985,0.00002428843,0.0002396284,0.00002489961,0.002471071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004381979,"threshold_uncertainty_score":0.01465923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009183651940097421,"score_gpt":0.2254598991905835,"score_spread":0.2162762472504861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}