{"id":"W2013435387","doi":"10.1089/aid.2012.0141","title":"Positional Adaptability in the Design of Mutation-Resistant Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: A Supramolecular Perspective","year":2012,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burman University","funders":"McGill University","keywords":"Supramolecular chemistry; RNase H; Reverse transcriptase; Stereochemistry; Chemistry; Computational biology; Combinatorial chemistry; Biology; Biochemistry; Crystallography; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002845261,0.0002117989,0.0002370089,0.0001359038,0.0001823004,0.0004264285,0.0003660019,0.0002850025,0.0008805379],"category_scores_gemma":[0.0001804303,0.0001552569,0.0002220136,0.000151748,0.0002925452,0.000562464,0.0004245646,0.0003454661,0.0002888603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336443,"about_ca_system_score_gemma":0.0001641757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001411841,"about_ca_topic_score_gemma":0.0002303701,"domain_scores_codex":[0.9999194,0.00001770701,0.000007173984,0.00001985546,0.00001722111,0.00001867385],"domain_scores_gemma":[0.9999546,0.00001042906,0.00001228084,0.0000071072,0.000004772617,0.00001081721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002390718,0.0002853671,0.0007849074,0.0005107062,0.0000361374,0.0006073265,0.00033397,0.03210181,0.871673,0.02645253,0.0005022861,0.06647292],"study_design_scores_gemma":[0.0002909705,0.006756122,0.003867743,0.0001404896,0.0001749975,0.001022726,0.0005332357,0.134743,0.7265099,0.02213525,0.1036673,0.0001580764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956487,0.01332357,0.07256261,0.001154065,0.0001919947,0.0001650108,0.00007744276,0.0003186513,0.01655799],"genre_scores_gemma":[0.9720391,0.005181953,0.0205226,0.0002018309,0.00004295421,0.0001023772,0.00005679301,0.00002353963,0.00182888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008805379,"threshold_uncertainty_score":0.002945721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09242584869322905,"score_gpt":0.3738508998285368,"score_spread":0.2814250511353077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}