{"id":"W2013435387","doi":"10.1089/aid.2012.0141","title":"Positional Adaptability in the Design of Mutation-Resistant Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: A Supramolecular Perspective","year":2012,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burman University","funders":"McGill University","keywords":"Supramolecular chemistry; RNase H; Reverse transcriptase; Stereochemistry; Chemistry; Computational biology; Combinatorial chemistry; Biology; Biochemistry; Crystallography; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001830322,0.0001404663,0.0002397285,0.0003383416,0.0002305848,0.00003315809,0.00009846652,0.00006249244,0.0001892173],"category_scores_gemma":[0.000296984,0.00009733735,0.00007166847,0.0003905514,0.0004602227,0.0001992227,0.00002983036,0.0003112792,0.00002520541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225097,"about_ca_system_score_gemma":0.0001876664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004230336,"about_ca_topic_score_gemma":0.00005033115,"domain_scores_codex":[0.997767,0.0005094974,0.0002865051,0.0002435526,0.000754158,0.000439249],"domain_scores_gemma":[0.9988983,0.0003644341,0.00003992357,0.0002407737,0.0002865891,0.0001699862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004286427,0.006407602,0.7521157,0.000331781,0.0005582385,0.0006381989,0.04311472,0.000003460527,0.07575095,0.102707,0.01353661,0.0005493216],"study_design_scores_gemma":[0.005707588,0.003829497,0.9210789,0.0003823221,0.0001914479,0.00007973295,0.03347536,0.00000899942,0.0252232,0.006828748,0.00283888,0.000355293],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953045,0.001170473,0.0001979925,0.001561257,0.0000148005,0.0008849921,0.00004683592,0.00001369054,0.0008054691],"genre_scores_gemma":[0.9974933,0.00004686631,0.001856592,0.00009192059,0.00007315514,0.00008902394,0.00003793389,0.00001409106,0.0002970939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1689632,"threshold_uncertainty_score":0.3969302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09242584869322905,"score_gpt":0.3738508998285368,"score_spread":0.2814250511353077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}