{"id":"W2013444912","doi":"10.1021/bi050517t","title":"Structure and Mechanism of Action of an Inverting Mutant Sialidase","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Sialidase; Mutant; Mechanism (biology); Mechanism of action; Action (physics); Chemistry; Process (computing); Stereochemistry; Biochemistry; Computer science; Philosophy; Enzyme; Physics; Epistemology; Neuraminidase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107731,0.0003055767,0.000235511,0.00009740885,0.000104863,0.0003771323,0.0003721921,0.0003977362,0.0003223898],"category_scores_gemma":[0.0001213253,0.0001384001,0.0002686603,0.00009076631,0.0002497735,0.000155358,0.0001490443,0.0004909332,0.000242847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007234542,"about_ca_system_score_gemma":0.0003237703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001799343,"about_ca_topic_score_gemma":0.0007857449,"domain_scores_codex":[0.9999192,0.000008951969,0.000009358037,0.00001709363,0.00003056907,0.00001486287],"domain_scores_gemma":[0.9999305,0.000007707811,0.00001964817,0.000008903523,0.00001144469,0.00002176126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001151809,0.00001541618,0.0004690803,0.00002590928,0.000008541724,0.0001757374,0.00001735573,0.000793424,0.9960546,0.0007894223,0.00003814163,0.001497172],"study_design_scores_gemma":[0.00002350489,0.0001516619,0.002110306,0.000005749529,0.00001664288,0.00039862,0.00002828339,0.01013731,0.9857276,0.0002739819,0.00111441,0.00001194756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961932,0.000502599,0.002183508,0.0001022474,0.00001955919,0.00001104002,0.0001202755,0.0000604263,0.0008072015],"genre_scores_gemma":[0.9974278,0.000301982,0.001385054,0.00002771891,0.000003154002,0.000005828559,0.0002024963,0.00001154186,0.000634397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001799343,"threshold_uncertainty_score":0.005249023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343219168116046,"score_gpt":0.2866000496981018,"score_spread":0.2731678580169414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}