{"id":"W2013444912","doi":"10.1021/bi050517t","title":"Structure and Mechanism of Action of an Inverting Mutant Sialidase","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Sialidase; Mutant; Mechanism (biology); Mechanism of action; Action (physics); Chemistry; Process (computing); Stereochemistry; Biochemistry; Computer science; Philosophy; Enzyme; Physics; Epistemology; Neuraminidase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008330309,0.0000770804,0.00008679224,0.00002183465,0.00002655479,0.000006466592,0.00008149262,0.000141459,0.00005148501],"category_scores_gemma":[0.0000768318,0.0000743236,0.00002830392,0.00004888167,0.00005775143,0.000004170563,0.00005400876,0.00005664481,3.724089e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007343023,"about_ca_system_score_gemma":0.00004916828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001476481,"about_ca_topic_score_gemma":0.000009856591,"domain_scores_codex":[0.999423,0.00001863225,0.0001587447,0.0001771533,0.0001207154,0.0001017752],"domain_scores_gemma":[0.9995542,0.000003225936,0.00008765301,0.0002061274,0.00008190545,0.0000668979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005914273,0.00002916907,0.0001323193,0.0000696639,0.00001164597,4.645128e-7,0.00002183343,0.000008521851,0.9926467,0.00006122168,0.00001854822,0.006940774],"study_design_scores_gemma":[0.0003243531,0.00008520664,0.0001221269,0.00001104261,0.000004972123,0.00001474837,0.00007297016,0.0005962925,0.9982496,0.00007284011,0.0003720516,0.00007378176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993227,0.0001218317,0.0001932759,0.00004459808,0.00001425352,0.00006951165,0.00003574854,0.000004453198,0.0001936726],"genre_scores_gemma":[0.998319,0.00002368354,0.001324502,0.00002543085,0.0001161977,0.000002299981,0.00007517138,0.000008333108,0.0001053708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006866992,"threshold_uncertainty_score":0.3030829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343219168116046,"score_gpt":0.2866000496981018,"score_spread":0.2731678580169414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}