{"id":"W2013489418","doi":"10.1038/mt.2014.172","title":"AAV8-Mediated In Vivo Overexpression of miR-155 Enhances the Protective Capacity of Genetically Attenuated Malarial Parasites","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Heidelberg Center for American Studies, University of Heidelberg; Institute of Infection and Immunity; Deutsches Zentrum für Infektionsforschung; Deutsches Krebsforschungszentrum","keywords":"In vivo; Biology; Genetically modified organism; Transgene; Virology; Malarial parasites; Genetically engineered; Cell biology; Malaria; Immunology; Gene; Plasmodium falciparum; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748909,0.0003185281,0.0002189709,0.000205898,0.00008032763,0.0002504276,0.0001867653,0.000267013,0.001164337],"category_scores_gemma":[0.0001181324,0.0001665487,0.0002105955,0.00007195798,0.0002505238,0.0002212043,0.0001514492,0.0006250717,0.0002449948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001827253,"about_ca_system_score_gemma":0.000166828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003107743,"about_ca_topic_score_gemma":0.0003629036,"domain_scores_codex":[0.9998344,0.00002759492,0.00002337657,0.00004794686,0.00003195083,0.00003475504],"domain_scores_gemma":[0.9999104,0.00001475533,0.00003072399,0.000009734176,0.000008183391,0.00002613292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007255415,0.00002740829,0.00005826139,0.0000275631,0.000002544692,0.00001713449,0.00001262038,0.00003085611,0.9988709,0.00008973548,0.00001936613,0.0007711199],"study_design_scores_gemma":[0.00002360417,0.0007513257,0.001088089,0.0000062705,0.00001905347,0.0001772081,0.00001834141,0.0008125047,0.9950817,0.00004084628,0.001977451,0.000003663555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925874,0.0006873048,0.004637419,0.000100535,0.00005343587,0.00005065425,0.0002114402,0.000180108,0.001491725],"genre_scores_gemma":[0.9918498,0.0004342003,0.004986071,0.00003895944,0.00001435955,0.00004690719,0.0002313053,0.00002574177,0.002372755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164337,"threshold_uncertainty_score":0.003895104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008951330056005177,"score_gpt":0.2496410748260622,"score_spread":0.240689744770057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}