{"id":"W2013489418","doi":"10.1038/mt.2014.172","title":"AAV8-Mediated In Vivo Overexpression of miR-155 Enhances the Protective Capacity of Genetically Attenuated Malarial Parasites","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Heidelberg Center for American Studies, University of Heidelberg; Institute of Infection and Immunity; Deutsches Zentrum für Infektionsforschung; Deutsches Krebsforschungszentrum","keywords":"In vivo; Biology; Genetically modified organism; Transgene; Virology; Malarial parasites; Genetically engineered; Cell biology; Malaria; Immunology; Gene; Plasmodium falciparum; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002427939,0.0001469447,0.0003510792,0.00005560343,0.00002553371,0.000006760563,0.0001458587,0.0001024994,0.0001566919],"category_scores_gemma":[0.0001965715,0.00009276636,0.0001400023,0.0001768696,0.0001397614,0.00002121403,0.00001942679,0.0001369275,0.000002966458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001382788,"about_ca_system_score_gemma":0.00005249726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812999,"about_ca_topic_score_gemma":0.00001239433,"domain_scores_codex":[0.9986779,0.0002706963,0.0003110565,0.0002261409,0.0003241627,0.0001900567],"domain_scores_gemma":[0.99916,0.0001059686,0.0001561365,0.0003654542,0.0001474801,0.00006494612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001628657,0.0002909831,0.004425922,0.00003399993,0.0000974088,0.000004999686,0.0002262247,0.00002606104,0.9905747,0.0002322897,0.0000200947,0.002438681],"study_design_scores_gemma":[0.003795427,0.0007359053,0.070524,0.000162388,0.00003825206,0.000002034951,0.00003476394,0.001520614,0.922178,0.0005682645,0.0003405091,0.00009985935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962057,0.0005288248,0.001587004,0.0004352292,0.00003571876,0.0009586322,0.00002096765,0.000013877,0.0002139909],"genre_scores_gemma":[0.9992219,0.00004941631,0.0001569856,0.0003950595,0.00004876878,0.00009144824,0.000008780248,0.00001522238,0.00001242941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0683967,"threshold_uncertainty_score":0.3782903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008951330056005177,"score_gpt":0.2496410748260622,"score_spread":0.240689744770057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}