{"id":"W2013504017","doi":"10.1038/ng.2962","title":"Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits","year":2014,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Hematocrit; Missense mutation; Genetics; Frameshift mutation; Exome; Genome-wide association study; Exome sequencing; White blood cell; Immunology; Mutation; Gene; Single-nucleotide polymorphism; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001015258,0.0004299907,0.0009087203,0.00006496297,0.00005901462,0.00003893795,0.0001523756,0.001509292,0.000004688983],"category_scores_gemma":[0.00007605609,0.0003036714,0.00008584951,0.000127378,0.0000881718,0.000001714351,0.00009016171,0.0003774476,0.000001081027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001308117,"about_ca_system_score_gemma":0.00007521317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002303694,"about_ca_topic_score_gemma":0.0001526089,"domain_scores_codex":[0.9985625,0.0001291475,0.0002806914,0.0006115689,0.0001247226,0.0002913666],"domain_scores_gemma":[0.9993671,0.00003191087,0.0002400759,0.0002219091,0.00004619436,0.00009276773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000764974,0.0009452976,0.09221486,0.01185299,0.00219585,0.0003903807,0.00009601916,0.000003558418,0.0001836814,0.0003451663,0.0006748927,0.8910208],"study_design_scores_gemma":[0.01062754,0.002096791,0.02945556,0.02806693,0.003974912,0.001326267,0.00010585,0.00003645284,0.0006273942,0.0009113562,0.918138,0.004632927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0355531,0.9635587,0.000010856,0.0000116888,0.00005119039,0.0004199333,0.0001455,0.000009386285,0.0002396566],"genre_scores_gemma":[0.05791892,0.9411792,0.0003184895,0.0001708299,0.00007367883,0.00003893518,0.0001961555,0.00005859753,0.00004520761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9174631,"threshold_uncertainty_score":0.9999415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144604181566516,"score_gpt":0.2744292486001456,"score_spread":0.2599688304434939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}