{"id":"W2013517216","doi":"10.1096/fj.06-6681com","title":"Estrogen receptor‐α mediates an intraovarian negative feedback loop on thecal cell steroidogenesis <i>via</i> modulation of <i>Cyp17a1</i> (cytochrome P450, steroid 17α‐hydroxylase/17,20 μlyase) expression","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Endocrinology; Internal medicine; CYP17A1; Theca; Ovary; Biology; Aromatase; Polycystic ovary; Estrogen receptor alpha; Testosterone (patch); Folliculogenesis; Androgen receptor; Estrogen receptor; Chemistry; Cell biology; Medicine; Insulin resistance; Insulin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184519,0.0003750242,0.0005710826,0.0001437903,0.0003582056,0.00003642722,0.0003401266,0.0002611391,0.0003139141],"category_scores_gemma":[0.00009285477,0.0002348691,0.0002349055,0.0002372285,0.0004374052,0.0002959857,0.00007311587,0.0006930531,0.0000499998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160816,"about_ca_system_score_gemma":0.0001261537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005652428,"about_ca_topic_score_gemma":0.00001072027,"domain_scores_codex":[0.9968998,0.0007975551,0.0007782079,0.0005285285,0.0005402605,0.0004556561],"domain_scores_gemma":[0.9978639,0.0002174819,0.0006032845,0.0007650628,0.0002981169,0.0002521457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006154525,0.0007699938,0.005416218,0.00002945257,0.00008430309,0.00001926277,0.0005310003,0.0008356738,0.9837683,0.00001402698,0.0007063673,0.001670826],"study_design_scores_gemma":[0.002352709,0.001463881,0.06648287,0.0001098029,0.0001459279,0.0001814607,0.0002407175,0.0006256349,0.9271294,0.0009349699,0.0001136537,0.0002189767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955593,0.0005076243,0.001284135,0.0007837453,0.0003021451,0.0005951301,0.00008573115,0.00004699378,0.0008352118],"genre_scores_gemma":[0.9967313,0.00005148512,0.0007950826,0.0002599969,0.00137323,0.00001470067,0.0001178168,0.00004284246,0.000613531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06106666,"threshold_uncertainty_score":0.9577686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542940861036469,"score_gpt":0.2408607184014209,"score_spread":0.2254313097910562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}