{"id":"W2013517216","doi":"10.1096/fj.06-6681com","title":"Estrogen receptor‐α mediates an intraovarian negative feedback loop on thecal cell steroidogenesis <i>via</i> modulation of <i>Cyp17a1</i> (cytochrome P450, steroid 17α‐hydroxylase/17,20 μlyase) expression","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"National Institute of Environmental Health Sciences; National Institutes of Health","keywords":"Endocrinology; Internal medicine; CYP17A1; Theca; Ovary; Biology; Aromatase; Polycystic ovary; Estrogen receptor alpha; Testosterone (patch); Folliculogenesis; Androgen receptor; Estrogen receptor; Chemistry; Cell biology; Medicine; Insulin resistance; Insulin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138909,0.0003088147,0.0002765281,0.000142375,0.0001468791,0.0003721416,0.0001594894,0.0001365356,0.001102294],"category_scores_gemma":[0.0002127262,0.0001848313,0.0002446486,0.00008365998,0.00032139,0.0001864409,0.0001942748,0.0003487468,0.0005747196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120677,"about_ca_system_score_gemma":0.000225056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006555058,"about_ca_topic_score_gemma":0.0007136796,"domain_scores_codex":[0.9998816,0.00002602304,0.000009388731,0.00002094938,0.00003285137,0.00002909879],"domain_scores_gemma":[0.9998071,0.00003461051,0.00004841763,0.00003635101,0.00003349534,0.00004010642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868794,0.00001597593,0.0009901453,0.00002747394,0.000007502273,0.0001030843,0.00002033117,0.00003096845,0.9962847,0.0001063628,0.0000622046,0.002164244],"study_design_scores_gemma":[0.00005660474,0.0005907021,0.03852689,0.00001822623,0.00005249136,0.0006354148,0.0001397734,0.0005682555,0.9514427,0.0002028103,0.007757741,0.000008345696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865866,0.003715618,0.004415579,0.0002323896,0.0001173392,0.00002631081,0.0003253055,0.000173985,0.004406834],"genre_scores_gemma":[0.99207,0.002328198,0.001158369,0.0001073812,0.00003522985,0.00001765838,0.0003756319,0.00002356754,0.003883944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102294,"threshold_uncertainty_score":0.003687561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542940861036469,"score_gpt":0.2408607184014209,"score_spread":0.2254313097910562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}