{"id":"W2013517683","doi":"10.1016/j.bmc.2006.03.035","title":"Chemoenzymatic synthesis of both enantiomers of α-tocotrienol","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Enantiomer; Acylation; Candida antarctica; Stereoselectivity; Lipase; Hydrolysis; Derivative (finance); Triacylglycerol lipase; Yield (engineering); Vinyl acetate; Organic chemistry; Tocotrienol; Chemical synthesis; Enzyme; Stereochemistry; Tocopherol; In vitro; Biochemistry; Catalysis; Antioxidant; Vitamin E","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688573,0.0004410654,0.000236552,0.0003212708,0.0002711567,0.0003503998,0.0003859173,0.0002955804,0.003087821],"category_scores_gemma":[0.000230203,0.0001930486,0.0002466986,0.0004965653,0.0002244187,0.0005332418,0.0004355065,0.0007547796,0.001103226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000472744,"about_ca_system_score_gemma":0.000564742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171032,"about_ca_topic_score_gemma":0.001926511,"domain_scores_codex":[0.9998176,0.00001917094,0.00001633346,0.00003722927,0.00003145009,0.00007824624],"domain_scores_gemma":[0.9999065,0.00001515137,0.00002096509,0.00001805843,0.00001419403,0.00002503385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002484182,0.00006949905,0.0001486268,0.0001270615,0.000009406077,0.0003019152,0.00006642431,0.000442528,0.9847212,0.002115191,0.0002316061,0.01151815],"study_design_scores_gemma":[0.00001283364,0.00007199556,0.0001676311,0.000004893546,0.000006855698,0.00009268946,0.00001957252,0.0001537542,0.9968675,0.0001108708,0.002486383,0.000005009282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400156,0.002762212,0.02577195,0.0005786053,0.0002521114,0.0001767683,0.001666841,0.0002575626,0.02851831],"genre_scores_gemma":[0.9846116,0.001991292,0.005938513,0.00008741227,0.00001753027,0.00003071815,0.0004152824,0.00003860396,0.006869036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003087821,"threshold_uncertainty_score":0.01032978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004601933961641587,"score_gpt":0.2097215406183181,"score_spread":0.2051196066566766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}