{"id":"W2013519952","doi":"10.1179/1973947812y.0000000063","title":"<i>In vitro</i>activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics","year":2013,"lang":"en","type":"article","venue":"Journal of Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Microbiology; Antibiotics; Staphylococcus aureus; Minimum inhibitory concentration; In vitro; Methicillin-resistant Staphylococcus aureus; Biology; Daptomycin; Pharmacology; Chemistry; Bacteria; Biochemistry; Vancomycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003422982,0.0004012781,0.0003570879,0.0002106156,0.0001010283,0.0002082336,0.0002359432,0.000304769,0.00108925],"category_scores_gemma":[0.000464753,0.0001338626,0.0002885861,0.000234226,0.0001577545,0.0001840555,0.0001084454,0.0003705374,0.0002804954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368985,"about_ca_system_score_gemma":0.0001845403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003362316,"about_ca_topic_score_gemma":0.002022652,"domain_scores_codex":[0.9996245,0.0001288316,0.00003806192,0.00004963046,0.00008307869,0.00007592863],"domain_scores_gemma":[0.9997142,0.0001241107,0.0000559497,0.00002536583,0.00004860049,0.00003181577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001398036,0.0001457105,0.0007426712,0.0001119707,0.000023737,0.00005045869,0.00003491161,0.0008644048,0.9911383,0.00007565146,0.0004222064,0.004991923],"study_design_scores_gemma":[0.00002269569,0.002825346,0.002885016,0.000007125038,0.00002129522,0.0001219907,0.00001491069,0.002365127,0.9906474,0.0000142319,0.00106719,0.000007746778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865507,0.004863329,0.002985975,0.0001060345,0.00006506711,0.0000647427,0.001295715,0.0001180768,0.003950419],"genre_scores_gemma":[0.992834,0.001335112,0.002201001,0.00005968526,0.00002882606,0.00004599759,0.001657714,0.00001757068,0.001820015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003362316,"threshold_uncertainty_score":0.006685495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008365583363074948,"score_gpt":0.2498912407139975,"score_spread":0.2415256573509225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}