{"id":"W2013520562","doi":"10.1158/1078-0432.ccr-14-0521","title":"Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee","year":2014,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health","keywords":"Clinical trial; Medicine; Regimen; Drug development; Clinical study design; Clinical endpoint; Pharmacodynamics; Combination therapy; Phases of clinical research; Pharmacology; Intensive care medicine; Medical physics; Oncology; Drug; Pharmacokinetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1885658,0.002558201,0.005830625,0.006553518,0.001217351,0.005657958,0.009003016,0.009508459,0.005297561],"category_scores_gemma":[0.186016,0.002392551,0.006698928,0.008148495,0.003654094,0.004008077,0.002719072,0.0131375,0.007276505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006069164,"about_ca_system_score_gemma":0.04705689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005725434,"about_ca_topic_score_gemma":0.008151147,"domain_scores_codex":[0.8847305,0.07558863,0.02159507,0.00219217,0.01459871,0.00129499],"domain_scores_gemma":[0.7633509,0.1241917,0.02379677,0.009476103,0.07452665,0.004658002],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007823624,0.0002282279,0.0003879181,0.03697242,0.0004934859,0.000172435,0.0004304432,0.001735061,0.0008652507,0.0206147,0.3083621,0.6289557],"study_design_scores_gemma":[0.001265641,0.0002723592,0.0009896026,0.06546559,0.001053589,0.0003217812,0.0001376442,0.001219822,0.0008967294,0.02033364,0.907927,0.0001166423],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0008139624,0.6029708,0.138197,0.1536255,0.01943177,0.04680429,0.004967182,0.001184876,0.03200464],"genre_scores_gemma":[0.006731423,0.4506321,0.4025011,0.05997411,0.005617402,0.05795179,0.005088222,0.0004427957,0.01106106],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.8114342,"threshold_uncertainty_score":0.997243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9658311449296211,"score_gpt":0.7722733089490966,"score_spread":0.1935578359805245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}