{"id":"W2013520562","doi":"10.1158/1078-0432.ccr-14-0521","title":"Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee","year":2014,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health","keywords":"Clinical trial; Medicine; Regimen; Drug development; Clinical study design; Clinical endpoint; Pharmacodynamics; Combination therapy; Phases of clinical research; Pharmacology; Intensive care medicine; Medical physics; Oncology; Drug; Pharmacokinetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2827977,0.0005278689,0.008029955,0.0002534757,0.0003188899,0.00005006148,0.003501273,0.001173648,0.0003286808],"category_scores_gemma":[0.7000216,0.0002979513,0.003161094,0.001686051,0.004260525,0.0000803514,0.001302834,0.004211872,0.00001123869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428105,"about_ca_system_score_gemma":0.005046067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003111483,"about_ca_topic_score_gemma":0.00000862899,"domain_scores_codex":[0.8086574,0.1688039,0.01778485,0.001060533,0.002978521,0.0007147825],"domain_scores_gemma":[0.2573996,0.7278359,0.009622315,0.00268787,0.002130551,0.0003237181],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.008031487,0.003507071,0.00002347847,0.01081533,0.001350716,6.630293e-7,0.00008392666,0.00001994757,0.000004244558,0.06117391,0.05510319,0.8598861],"study_design_scores_gemma":[0.0449662,0.00305142,0.00001459865,0.02453294,0.00354817,0.000001237304,0.00003987926,0.000856867,0.0001238686,0.8146475,0.1077106,0.0005066787],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.0001775712,0.3663672,0.5711983,0.004466681,0.01482,0.04017327,0.002314503,0.00008287941,0.0003995011],"genre_scores_gemma":[0.0002694418,0.7912688,0.2036626,0.0001023112,0.002079498,0.001775056,0.00001913837,0.0001744611,0.0006486825],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.8593794,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9658311449296211,"score_gpt":0.7722733089490966,"score_spread":0.1935578359805245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}