{"id":"W2013523663","doi":"10.1371/journal.pone.0006438","title":"Manipulation of Signaling Thresholds in “Engineered Stem Cell Niches” Identifies Design Criteria for Pluripotent Stem Cell Screens","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Stem cell; Biology; Embryonic stem cell; Cell biology; Cell fate determination; Niche; Cellular differentiation; Induced pluripotent stem cell; Signal transduction; Transcription factor; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000726481,0.00058098,0.0004669938,0.0004654728,0.0002164873,0.0007813617,0.0004315819,0.0004057948,0.0007277064],"category_scores_gemma":[0.00189465,0.0003899539,0.0002249657,0.0002642872,0.0004933145,0.0004953136,0.0004644361,0.0005358012,0.0002857132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000634597,"about_ca_system_score_gemma":0.0003355639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026401,"about_ca_topic_score_gemma":0.0006726034,"domain_scores_codex":[0.9991315,0.0002171906,0.0001039737,0.000119858,0.0003613534,0.0000661037],"domain_scores_gemma":[0.9985178,0.000859198,0.0003178595,0.0001118391,0.0001134259,0.00007990792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004328714,0.00001884459,0.0003647617,0.00004764538,0.000004402657,0.00005158768,0.0000202483,0.002125668,0.9928836,0.0005859904,0.00003620834,0.00381775],"study_design_scores_gemma":[0.000009821097,0.0001210553,0.0009656819,0.000006628261,0.00001117538,0.0001201002,0.00001858619,0.00748856,0.9898566,0.0003920929,0.0009995875,0.00001012296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8322956,0.001385465,0.1609605,0.0002829374,0.0000285402,0.0002670021,0.0003692135,0.0008778707,0.003532837],"genre_scores_gemma":[0.9401105,0.0004846652,0.05798673,0.00008879352,0.000009551885,0.0002101882,0.0001842389,0.0001619422,0.0007633671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007813617,"threshold_uncertainty_score":0.00460434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1132606153856795,"score_gpt":0.273583938457076,"score_spread":0.1603233230713964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}