{"id":"W2013537032","doi":"10.1158/1078-0432.ccr-05-0209","title":"Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity <i>In vivo</i>","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Biological Activity of Diterpenoids and Biflavonoids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"In vivo; Biology; Microtubule polymerization; Multiple drug resistance; Apoptosis; Cell cycle checkpoint; Cell culture; P-glycoprotein; Microtubule; Mechanism of action; Cell cycle; Tubulin; Cytotoxicity; Cell biology; Pharmacology; Drug resistance; Biochemistry; In vitro; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006632026,0.0002801105,0.0001527577,0.0002051393,0.0001284584,0.0001569708,0.0001598383,0.0002108153,0.0006685207],"category_scores_gemma":[0.00005122154,0.00005207101,0.0001295845,0.000126392,0.0001484297,0.0001916147,0.000114557,0.0002631166,0.0002379933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001566477,"about_ca_system_score_gemma":0.0001635063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00020188,"about_ca_topic_score_gemma":0.0003369655,"domain_scores_codex":[0.9999657,0.000007055507,0.000003057525,0.000006881125,0.000009453926,0.000007915384],"domain_scores_gemma":[0.9999629,0.000004234244,0.00001278567,0.000004198457,0.000007262284,0.000008631911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002239676,0.00006424708,0.0002623133,0.000120147,0.00000684487,0.0001260561,0.000007374023,0.0001553153,0.9899323,0.0001708436,0.0001438758,0.008786637],"study_design_scores_gemma":[0.00008739882,0.001804422,0.003962182,0.000009822771,0.00003841192,0.001025745,0.00001134171,0.0009435703,0.9821205,0.00007398474,0.009913545,0.000009037603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772275,0.01313657,0.005395944,0.0002391963,0.00006155718,0.00007472845,0.0003616484,0.0001481853,0.00335475],"genre_scores_gemma":[0.990306,0.004229191,0.00329728,0.0001289132,0.00003394888,0.00004178847,0.0005231622,0.00001301826,0.001426535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006685207,"threshold_uncertainty_score":0.002236426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1449346952063731,"score_gpt":0.4273523832548519,"score_spread":0.2824176880484788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}