{"id":"W2013537032","doi":"10.1158/1078-0432.ccr-05-0209","title":"Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity <i>In vivo</i>","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Biological Activity of Diterpenoids and Biflavonoids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"In vivo; Biology; Microtubule polymerization; Multiple drug resistance; Apoptosis; Cell cycle checkpoint; Cell culture; P-glycoprotein; Microtubule; Mechanism of action; Cell cycle; Tubulin; Cytotoxicity; Cell biology; Pharmacology; Drug resistance; Biochemistry; In vitro; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002363443,0.0002359252,0.0003901361,0.00007893348,0.0002072945,0.0000838101,0.0004063756,0.00038274,0.00007152611],"category_scores_gemma":[0.0004913713,0.0002012229,0.0001449453,0.0002395317,0.0005980587,0.00002705152,0.0005248727,0.0008550015,0.00001548253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000094732,"about_ca_system_score_gemma":0.0001755741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000197983,"about_ca_topic_score_gemma":0.002420671,"domain_scores_codex":[0.9970254,0.0004255484,0.0003936063,0.001038427,0.0003865919,0.0007304664],"domain_scores_gemma":[0.9988007,0.0002141413,0.0001121115,0.0004613946,0.0001418727,0.0002697745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007607398,0.0007870807,0.03635341,0.00006954629,0.00002823482,0.000007013305,0.00003055539,0.000003078664,0.9405074,0.00001861873,0.001081116,0.02035328],"study_design_scores_gemma":[0.003288535,0.000707483,0.1695978,0.0002142482,0.00001602189,0.00000534802,0.00006529115,0.0001438125,0.7378781,0.0001120247,0.08736898,0.0006023501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934145,0.003220011,0.0001771239,0.001918417,0.0001433366,0.0004953579,0.00007910551,0.00001621853,0.00053588],"genre_scores_gemma":[0.9941064,0.002934453,0.001036983,0.0004685591,0.0005592611,0.0000796047,0.000009411636,0.00002811177,0.0007771989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2026292,"threshold_uncertainty_score":0.8205633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1449346952063731,"score_gpt":0.4273523832548519,"score_spread":0.2824176880484788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}