{"id":"W2013619233","doi":"10.1016/j.steroids.2012.06.004","title":"Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer","year":2012,"lang":"en","type":"article","venue":"Steroids","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Doxorubicin; Estrogen receptor; Conjugate; Estrogen; Chemistry; Pharmacology; Estrone; Breast cancer; Cancer; Cancer research; Internal medicine; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002085937,0.0003231345,0.0005178201,0.00006189413,0.00009344869,0.00000840783,0.00011015,0.0003209362,0.0000433183],"category_scores_gemma":[0.00001937167,0.0002779272,0.0002313871,0.00008453112,0.0002536685,0.00001879544,0.0000760143,0.00006299307,0.000003633842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011552,"about_ca_system_score_gemma":0.00008292308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000115807,"about_ca_topic_score_gemma":0.000005170208,"domain_scores_codex":[0.9984998,0.0002298139,0.0003588657,0.0003672292,0.0001554415,0.0003888133],"domain_scores_gemma":[0.9988363,0.000153283,0.0003733203,0.0003028232,0.0001647975,0.0001694528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003558918,0.0005265543,0.01965598,0.00008165188,0.0005340868,4.954197e-7,0.0002908082,0.00002521915,0.9688122,0.00003763771,0.0001594209,0.006317011],"study_design_scores_gemma":[0.001323798,0.002119715,0.003674388,0.00007593258,0.0002511492,0.0000249702,0.0000635028,0.00001610842,0.991908,0.000005186915,0.0003063051,0.0002309845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887235,0.007968139,0.0003489465,0.00006272576,0.0001593402,0.0009454007,0.001748314,0.00001082032,0.00003276809],"genre_scores_gemma":[0.9955007,0.00166455,0.002094618,0.000007352152,0.0002192309,0.0001772128,0.0002366505,0.00004351896,0.00005610812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02309575,"threshold_uncertainty_score":0.9999673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316963312242629,"score_gpt":0.2523900808928219,"score_spread":0.2392204477703956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}