{"id":"W2013653499","doi":"10.1128/jvi.03664-13","title":"Boosting Functional Avidity of CD8 <sup>+</sup> T Cells by Vaccinia Virus Vaccination Depends on Intrinsic T-Cell MyD88 Expression but Not the Inflammatory Milieu","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"NIH Clinical Center","keywords":"Avidity; Biology; Cytotoxic T cell; T-cell receptor; CD8; T cell; Adoptive cell transfer; Priming (agriculture); DNA vaccination; Immunology; Virology; Cell biology; Antigen; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001302978,0.0003528139,0.0002364381,0.00006105384,0.0000775705,0.0002618204,0.0001702645,0.0002957047,0.001402126],"category_scores_gemma":[0.00013725,0.00007049506,0.0001529839,0.00004927318,0.0002436783,0.0001852533,0.0001873485,0.0005353855,0.0004753941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001775745,"about_ca_system_score_gemma":0.0001442277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007966982,"about_ca_topic_score_gemma":0.00008844703,"domain_scores_codex":[0.9998522,0.00002748526,0.00001727157,0.0000287287,0.00002195753,0.00005233604],"domain_scores_gemma":[0.999889,0.000023714,0.00003792324,0.00001466105,0.00001716946,0.00001755334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349076,0.00003475957,0.0006095477,0.00007729965,0.0000029845,0.0000241663,0.00000756087,0.00004959554,0.9965119,0.00004483909,0.00002796811,0.002374633],"study_design_scores_gemma":[0.00003471764,0.001222508,0.01062353,0.00001989344,0.00002502355,0.0005814712,0.00003065376,0.000992371,0.9844329,0.00006116516,0.001972372,0.000003435899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947032,0.001856946,0.002378655,0.0001052543,0.00003095655,0.00002386661,0.0001469207,0.00006066342,0.0006934508],"genre_scores_gemma":[0.9966576,0.0005576484,0.001893255,0.00006101642,0.00002516791,0.00002575903,0.0001774303,0.00001223419,0.0005898974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402126,"threshold_uncertainty_score":0.004690647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00915971293139018,"score_gpt":0.2060914449355598,"score_spread":0.1969317320041697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}