{"id":"W2013658560","doi":"10.1038/leu.2013.151","title":"Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target","year":2013,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health; Medical College of Wisconsin; National Heart, Lung, and Blood Institute; Sundhed og Sygdom, Det Frie Forskningsråd; Leukemia and Lymphoma Society","keywords":"Progenitor cell; Chronic myelogenous leukemia; Cancer research; Haematopoiesis; Bcl-xL; Bone marrow; Biology; Stem cell; CD34; Apoptosis; Stromal cell; Leukemia; Immunology; Medicine; Programmed cell death; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001730168,0.0003688532,0.0006607531,0.0000576466,0.0001646179,0.00004395762,0.000181223,0.0001604787,0.000315317],"category_scores_gemma":[0.0001011886,0.000284554,0.0001701203,0.0001729347,0.0001071187,0.0001937011,0.0001121035,0.0001254991,0.00004120399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001104495,"about_ca_system_score_gemma":0.00171042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001984363,"about_ca_topic_score_gemma":0.0000119221,"domain_scores_codex":[0.9975355,0.00002731941,0.00060245,0.0007044731,0.0003670437,0.0007632105],"domain_scores_gemma":[0.9981923,0.0001570866,0.0003004477,0.0006702551,0.0002058623,0.0004741201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003543362,0.0005896509,0.13271,0.004476577,0.001517472,0.00005133013,0.002994613,0.0001211273,0.004824227,0.0003366056,0.7185791,0.130256],"study_design_scores_gemma":[0.08215688,0.002354818,0.1810973,0.01460766,0.002306763,0.0001059623,0.0008237298,0.07841592,0.06276251,0.0178089,0.5550156,0.002544005],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692618,0.007791592,0.006140837,0.006740231,0.0003764195,0.008980413,0.0001052241,0.000127069,0.000476373],"genre_scores_gemma":[0.9043563,0.0004755538,0.05708094,0.002013818,0.000393607,0.001105716,0.000203195,0.0001272193,0.03424364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1635635,"threshold_uncertainty_score":0.9999607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132524855511329,"score_gpt":0.3029187906383001,"score_spread":0.2715935420831868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}