{"id":"W2013658560","doi":"10.1038/leu.2013.151","title":"Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target","year":2013,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute; National Institutes of Health; Medical College of Wisconsin; National Heart, Lung, and Blood Institute; Sundhed og Sygdom, Det Frie Forskningsråd; Leukemia and Lymphoma Society","keywords":"Progenitor cell; Chronic myelogenous leukemia; Cancer research; Haematopoiesis; Bcl-xL; Bone marrow; Biology; Stem cell; CD34; Apoptosis; Stromal cell; Leukemia; Immunology; Medicine; Programmed cell death; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596589,0.000183264,0.0001759673,0.0002666367,0.0002994165,0.000607318,0.0002337346,0.0001848047,0.003813027],"category_scores_gemma":[0.0001973246,0.0001065652,0.00009698528,0.0001859039,0.0002551305,0.0005491899,0.000345644,0.0006852334,0.0006302912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004540646,"about_ca_system_score_gemma":0.0003301628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002938706,"about_ca_topic_score_gemma":0.0006347101,"domain_scores_codex":[0.9998615,0.00002119143,0.000009538846,0.00002174986,0.00005332695,0.00003271646],"domain_scores_gemma":[0.999811,0.00001846054,0.00006432127,0.00001877674,0.00003159559,0.00005586597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008747019,0.00008188222,0.004478634,0.00008912345,0.00002599985,0.0003691772,0.00003261041,0.0001778683,0.9625,0.004124788,0.001065826,0.02617931],"study_design_scores_gemma":[0.0001965441,0.0008282514,0.05015181,0.00003681351,0.00008072588,0.003726602,0.0002206507,0.002469281,0.8887372,0.002361997,0.0511733,0.00001684616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639589,0.01104186,0.006380736,0.002498013,0.0001792723,0.00003519334,0.0009548312,0.000336027,0.01461522],"genre_scores_gemma":[0.9940719,0.001194303,0.001037456,0.0001040361,0.00002682912,0.000008811368,0.000514413,0.0000137474,0.003028465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003813027,"threshold_uncertainty_score":0.01275587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03132524855511329,"score_gpt":0.3029187906383001,"score_spread":0.2715935420831868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}