{"id":"W2013669259","doi":"10.1128/mbio.01117-13","title":"Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii","year":2014,"lang":"en","type":"article","venue":"mBio","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institute for Advanced Research; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Inflammasome; Innate immune system; AIM2; Pyroptosis; Toxoplasma gondii; Caspase 1; Biology; Proinflammatory cytokine; Signal transducing adaptor protein; Cell biology; Interleukin 18; Pyrin domain; Immunity; Immune system; Immunology; Cytokine; Signal transduction; Inflammation; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955467,0.0003980123,0.0002060644,0.0001902769,0.0001313171,0.0002393368,0.0001621233,0.0004687863,0.001122981],"category_scores_gemma":[0.0001428061,0.0001107241,0.000196989,0.00008348226,0.0003317255,0.0002610912,0.0002351033,0.000629758,0.0003909466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538629,"about_ca_system_score_gemma":0.000163458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006914847,"about_ca_topic_score_gemma":0.00008623362,"domain_scores_codex":[0.9998419,0.00003010145,0.00002140885,0.00003016643,0.00003766002,0.0000386042],"domain_scores_gemma":[0.9997954,0.0000248503,0.0001009269,0.00001715455,0.0000197282,0.0000419341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005325421,0.00002833142,0.0006791438,0.00009165682,0.000004009912,0.0001560852,0.00002016033,0.00005363367,0.9967243,0.0001275258,0.00004558646,0.001537009],"study_design_scores_gemma":[0.0001050447,0.001003716,0.01209231,0.00003596528,0.00004593436,0.002536685,0.0000597062,0.000622341,0.9798651,0.0002538027,0.003371159,0.000008348374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985155,0.007064885,0.004724858,0.0003749602,0.00005284814,0.00006273035,0.0005310904,0.0002333282,0.001800293],"genre_scores_gemma":[0.9933711,0.001460142,0.003178832,0.0001064794,0.00002411919,0.00005744871,0.0003730136,0.00002785015,0.001400843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001122981,"threshold_uncertainty_score":0.003756762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003073997795944513,"score_gpt":0.2067222879699084,"score_spread":0.2036482901739639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}