{"id":"W2013669259","doi":"10.1128/mbio.01117-13","title":"Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii","year":2014,"lang":"en","type":"article","venue":"mBio","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institute for Advanced Research; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust; Crohn's and Colitis Foundation of America","keywords":"Inflammasome; Innate immune system; AIM2; Pyroptosis; Toxoplasma gondii; Caspase 1; Biology; Proinflammatory cytokine; Signal transducing adaptor protein; Cell biology; Interleukin 18; Pyrin domain; Immunity; Immune system; Immunology; Cytokine; Signal transduction; Inflammation; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882557,0.0001389857,0.0001459154,0.00005996351,0.00005881565,0.00002184482,0.00009236633,0.0001190844,0.000007465871],"category_scores_gemma":[0.0001394736,0.0001435202,0.00004653574,0.00007421017,0.00003859454,0.000004626547,0.00008366809,0.00005676798,0.00001446132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009295823,"about_ca_system_score_gemma":0.00001908856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001375162,"about_ca_topic_score_gemma":0.0005179478,"domain_scores_codex":[0.9991276,0.00003098766,0.0001885269,0.0003056826,0.00006098235,0.0002862768],"domain_scores_gemma":[0.9995885,0.00001623014,0.00003877009,0.0002535086,0.00004230805,0.00006063225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005893926,0.00005435285,0.007769763,0.00006759693,0.00003129043,0.000002903227,0.0003750673,0.0000890736,0.9804043,0.0008366935,0.003995744,0.005783801],"study_design_scores_gemma":[0.001361566,0.000317591,0.0111747,0.00001905057,0.000007400808,0.000003708139,0.0001628251,0.00007055511,0.4370854,0.0003338687,0.5491787,0.0002845891],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996099,0.0003141426,0.0001318499,0.0005500789,0.00007960002,0.0002799348,0.00001411931,0.00001060666,0.002520648],"genre_scores_gemma":[0.9936813,0.00004671183,0.0008204695,0.0003573616,0.0001345356,0.00006328942,0.00007162595,0.0000229422,0.004801801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.545183,"threshold_uncertainty_score":0.5852582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003073997795944513,"score_gpt":0.2067222879699084,"score_spread":0.2036482901739639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}