{"id":"W2013699978","doi":"10.1016/j.nucmedbio.2004.06.009","title":"Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin","year":2004,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Petroleum Technology Alliance Canada","keywords":"Doxepin; Histamine; Histamine H1 receptor; Positron emission tomography; Metabolite; Receptor; Chemistry; Nuclear medicine; Pharmacology; Medicine; Biochemistry; Antagonist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003931887,0.0005628416,0.0003915413,0.0002229114,0.0001835,0.0003293357,0.0004562963,0.0006085386,0.001645666],"category_scores_gemma":[0.0004015424,0.0003921576,0.0001667022,0.0001936617,0.0003029266,0.0003416502,0.0003139105,0.0005553841,0.0004201136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959865,"about_ca_system_score_gemma":0.0002895115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001289267,"about_ca_topic_score_gemma":0.003232541,"domain_scores_codex":[0.9998622,0.00004647981,0.000008152946,0.00004036519,0.00002474671,0.00001800401],"domain_scores_gemma":[0.9998945,0.00003677213,0.00001142974,0.00002479921,0.00001860903,0.00001387815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009506958,0.00005690073,0.001654816,0.0001669801,0.00004643899,0.0003521977,0.00004911426,0.0003465785,0.9756024,0.000268844,0.0005727631,0.01993238],"study_design_scores_gemma":[0.0001348095,0.001842231,0.03078308,0.00003498308,0.0004180844,0.007920882,0.00009449613,0.007402847,0.9413133,0.0004800154,0.00952992,0.00004541651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6753513,0.009866262,0.3032019,0.0005319627,0.0001687469,0.0006384822,0.001348588,0.001074311,0.007818362],"genre_scores_gemma":[0.8666369,0.00422265,0.1203938,0.000489887,0.00004305767,0.0006380384,0.00131824,0.0001827453,0.006074648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001645666,"threshold_uncertainty_score":0.005505264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1352972865320764,"score_gpt":0.3469095958589301,"score_spread":0.2116123093268537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}